Results 61 to 70 of about 4,951,721 (322)

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

open access: yesFEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez   +3 more
wiley   +1 more source

Series of interpretation on Yellow Emperor'S Internal Classic (III): Unity of spirit and body: Views from Huang Di Nei Jing (《黄帝内经》Yellow Emperor's Internal Classic)

open access: yesChinese Medicine and Culture, 2018
Human life activities are inevitably affected by the surrounding environment , such as natural and social environment. It is the basic principle of TCM to set a series of medical practice activities.
Qingqi Wang
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

open access: yesFEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke   +2 more
wiley   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

open access: yesFEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

A stepwise emergence of evolution in the RNA world

open access: yesFEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Influence of environmental factors on the psychoemotional condition of schoolboys of middle classes of the capital megalopolis

open access: yesRUDN Journal of Ecology and Life Safety, 2015
Article is devoted to studying to impact of complex factors of environment mega polis on a psycho-emotional condition of the Moscow schoolboys of middle classes.
M N Danacheva, S A Shastun
doaj  

The geographical patterns of Chinese liquors during 1995–2004

open access: yesJournal of Maps, 2017
Chinese liquors come from a variety of different regions in China. This diversity can be attributed to the difference in microorganisms, but also to the biophysical environment. The latter constitutes a significant basis for the fermentation of products,
Xilin Zhao, Ya Tang, Chaosheng Zhang
doaj   +1 more source

The Social Data Environment

open access: yes, 2014
In previous work, we have introduced the data environment as a powerful explanatory concept in the realm of data privacy, with specific regard to the concepts of anonymisation and statistical disclosure. Here, we explain the concept more fully and examine how the socio technical system, that is titled social media, embodies and transforms the social ...
Elliot, Mark, Mackey, Elaine
openaire   +3 more sources

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

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