Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Validation of the Questionnaire on Reading Preferences and Habits of Primary School Pupils at Risk of Social Exclusion [PDF]
, 2022 Magdalena Ramos Navas-Parejo +3 more
openalex +1 more source
Social Exclusion Orderings [PDF]
We consider the problem of measuring social exclusion using qualitative data. We suggest a class of social exclusion indicators deriving the partial orderings associated with dominace for these indicators.
Claudio Zoli, Satya R. Chakravarty
core
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Poverty, Social Exclusion and Neighbourhood: Studying the area bases of social exclusion [PDF]
Are-based policies have become a significant part of the new Labour Government's approach to tackling social exclusion. This paper reviews the long-running debate about whether area-based policies can make a significant impact on poverty and social ...
Anne Power +3 more
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Rural Poverty Today: Experiences of Social Exclusion in Rural Britain. By Mark Shucksmith, Jayne Glass, Polly Chapman, and Jane Atterton. Bristol, UK: Policy Press, University of Bristol, 2023. 253 pp. Hardcover. $120.00. ISBN 978‐1‐4473‐6712‐3. [PDF]
Fredrik Ludwik Jhon Wanimbo +1 more
openalex +1 more source
The European Union Against Social Exclusion [PDF]
, 2004 [Excerpt] Social inclusion means that people who are poor or have other problems take part in the life of society.
Inclusion Europe
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
SOCIAL EXCLUSION OF PEOPLE WITH DISABILITIES: SUCCESFUL STRATEGIES FOR OVERCOMING
, 2016 Софья Владимировна Коржук
openalex +2 more sources