Results 141 to 150 of about 11,754,435 (295)

Physical, Psychological, Cognitive and Social Frailty Domains in Community-Dwelling Adults Aged 45–85: a Cross-sectional Analysis of the Canadian Longitudinal Study on Aging (CLSA)

Canadian Geriatrics Journal
Background Reported estimates of frailty prevalence vary considerably. At least partially attributable to differences in the conceptualization of frailty used, a better understanding of the interre-lationships among frailty domains could clarify ...
Lauren E. Griffith, Graciela Muniz Terrera, Edwin van den Heuvel, Jayati Khattar, David B. Hogan, Megan O’Connell, Mélanie Levasseur, Parminder Raina   +7 more
doaj   +1 more source

Frailty syndrome: an overview

, 2014
Xujiao Chen,1 Genxiang Mao,1 Sean X Leng2 1Department of Geriatrics, Zhejiang Hospital, Hangzhou, People's Republic of China; 2Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine ...
Leng SX, Mao GX, Chen XJ
core  

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

Close relationships and risk of frailty: the Hertfordshire cohort study [PDF]

, 2012
Syddall, H.E., Brunner, Eric J, Sayer, A.A., Sayer, AA, Brunner, E.J., Gale, CR, Cooper, C., Bergman, H., Gale, Catharine R., Bergman, Howard, Bergman, H, Cooper, Cyrus, Cooper, C, Gale, C.R., Syddall, HE, Syddall, Holly E, Sayer, Avan Aihie, Brunner, EJ   +17 more
core   +1 more source

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Frailty-aware surgical care: Validation of Hospital Frailty Risk Score (HFRS) in older surgical patients

Introduction: Frailty has an important impact on the health outcomes of older patients, and frailty screening is recommended as part of perioperative evaluation.
Simon Conroy, Xiaoting Huang, Barbara Helen Rosario, Kah Meng Kwok, Kangqi Ng, Li Fang Yeo, Michelle Bee Hua Tan, Sarah Kher Ru Sim, Lydia Euphemia Sim, Christine Shi Min Chau, Ting Yu Chang, Samuel Cheng En Ee, Aileen Lim, Wei Shyan Siow   +13 more
core   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

The relationship between frailty and social vulnerability:a systematic review

The Lancet Healthy Longevity
Both frailty (reduced physiological reserve) and social vulnerability (scarcity of adequate social connections, support, or interaction) become more common as people age and are associated with adverse consequences. Analyses of the relationships between these constructs can be limited by the wide range of measures used to assess them.
Hanlon, Peter, Wightman, Heather, Politis, Marina, Kirkpatrick, Stella, Jones, Caitlin, Andrew, Melissa K, Vetrano, Davide L, Dent, Elsa, Hoogendijk, Emiel O   +8 more
openaire   +2 more sources