Results 161 to 170 of about 11,754,435 (295)

Physical frailty predicts adverse outcomes in hospitalized patients with acute decompensation of cirrhosis

reservedBACKGROUND AND AIM: Patients with end-stage liver disease are at high risk of malnutrition, sarcopenia and frailty. Recent evidence indicates that physical frailty, as assessed by liver frailty index (LFI), is an independent predictor of ...
D'ARCANGELO, FRANCESCA
core  

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Social frailty and related social vulnerabilities among older adults in the Philippines: A narrative review. [PDF]

Int J Nurs Stud Adv
Soberano JI, Montayre J.
europepmc   +1 more source

Influence of ACE inhibitors on frailty, cardiac contractile function and calcium homeostasis in middle-aged male and female mice

, 2016
Angiotensin Converting Enzyme (ACE) inhibitors were chronically administered to middle-aged male and female mice to determine whether treatment with ACE inhibitors attenuates frailty and whether this is accompanied by changes in cardiac function.
Keller, Kaitlyn
core  

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

The Association Between Frailty and Depression of Older Adults with Cancer in China: The Mediating Effect of Social Support [PDF]

Nannan Jiang,1 Yichen Su,1 Yanli Zhang2 1School of Nursing, Bengbu Medical University, Bengbu, Anhui Province, 23000, People’s Republic of China; 2First Nursing Department, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui ...
Zhang Y, Su Y, Jiang N
core  

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source

Beyond Physical Impairment: The Role of Social Frailty in Heart Failure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Neil Keshvani, Ambarish Pandey
doaj   +1 more source

SOCIAL AND PHYSICAL NEIGHBOURHOOD ASPECTS AS BALANCING FACTORS FOR FRAILTY AND FRAILTY OUTCOMES [PDF]

Innovation in Aging, 2018
D Duppen, S Dury, L De Donder, D Consortium   +3 more
openaire   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source