Results 181 to 190 of about 11,754,435 (295)

Detection of social frailty in older adults: validation and reliability of the Makizako Social Frailty Index for Turkish older adults, a cross-sectional study. [PDF]

BMC Geriatr
Atbas C, Sayin H, Karaduman D, Sahiner Z, Hafizoglu M, Pehlivan M, Balci C, Dogu BB, Halil M, Cankurtaran M.   +9 more
europepmc   +1 more source

Integrating Frailty and Physical Resilience to Improve Risk Estimation in Aging Populations

Background: Physical resilience, broadly defined as the ability to resist or recover from health stressors, is a relatively new concept in the field of aging, yet, anticipated as a potentially game-changing idea.
Smith, Nathan Kyle
core  

Acid‐Responsive Nanobot‐Integrated Core‐Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis

Advanced Science, EarlyView.
An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan, Yan Zheng, Yue Lan, Zhuo Cheng, Siya Wang, Changqing Li, Yanqiu Wang, Minghan Liu   +7 more
wiley   +1 more source

Comparison of Social Frailty and Oral Health Literacy Among Older Adults in Urban and Rural Areas: A Cross-Sectional Study. [PDF]

Clin Interv Aging
Ichinomiya M, Shirayama Y, Fujiwara S, Kitamura M, Suma S, Kataoka K.   +5 more
europepmc   +1 more source

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee, Gayeon Kim, Ellison R. Black, Seonil Kim   +3 more
wiley   +1 more source

Programmable Self‐Heating Microneedle Patch for on‐Demand Postprandial Glucose Management

Advanced Science, EarlyView.
A programmable self‐heating microneedle patch enables on‐demand, timed‐sequence insulin delivery via user‐triggered quadrant activation. Each activation generates localized heat that melts a phase‐change barrier, accelerating drug release. In diabetic rats, sequential quadrant activation counteracts four meal‐mimicking glucose spikes over 24 h without ...
Yang Zhao, Guifang Pan, Jincai Zhang, Yue Gong, Wenjian Zhang, Huiling Shen, Xingxing Li, Yuehan Ouyang, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Analysis of the actor⁃partner interdependence model of self⁃differentiation and social frailty in patients with spinal tumor and their spouse

Huli yanjiu
ObjectiveTo explore the impact of self⁃differentiation on social frailty in patients with spinal tumor and their spouse.MethodsA total of 258 pairs of hospitalized patients with spinal tumor and their spouse from two tertiary grade A hospitals in Weifang
LIANG Xiaolei, QIN Dechun, XIA Xiaoyan, LIU Zixian, HAN Huimin, FENG Jiahang   +5 more
doaj  

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

Advanced Science, EarlyView.
CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and
Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni   +11 more
wiley   +1 more source

Comment on "Adverse Childhood Experiences and Social Frailty Trajectory Among Middle-Aged and Older Adults: A Network Analysis From a Population-Based Sample". [PDF]

Geriatr Gerontol Int
Liu M.
europepmc   +1 more source