Results 171 to 180 of about 11,754,435 (295)

"I Have Always Existed, but Never Been Noticed": A Hermeneutic Phenomenological Study of Social Frailty Among Prostate Cancer Survivors. [PDF]

J Multidiscip Healthc
Ye J, Zhuang S, Gu Y, Li N, Wan Y, Shen L, Xie C.   +6 more
europepmc   +1 more source

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

Advanced Science, EarlyView.
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He   +6 more
wiley   +1 more source

Construction and validation of a prediction model for social frailty in elderly patients undergoing maintenance hemodialysis

Huli yanjiu
ObjectiveTo construct a prediction model for social frailty in elderly patients undergoing maintenance hemodialysis.To explore the predictive value of modifiable factors such as dialysis symptom burden,family function,depression,and physical activity for
FAN Chenrui, LIU Junying
doaj  

COGNITIVE FRAILTY AND ITS RELATION WITH PHYSICAL, PSYCHOLOGICAL, SOCIAL AND ENVIRONMENTAL FRAILTY [PDF]

Innovation in Aging, 2017
E.E. DeRoeck, A. van der Vorst, S. Engelborghs, E. Dierckx   +3 more
openaire   +1 more source

Frailty and social support of the elderly in contexts of social vulnerability

, 2018
Objetivo: analisar a relação entre o nível de fragilidade e as relações familiares e sociais de idosos em contexto de vulnerabilidade social. Métodos: estudo transversal, realizado com idosos cadastrados em cinco Centros de Referência de Assistência Social. Amostra por conveniência composta por 247 idosos. Para coleta de dados, utilizou-se questionário
Jesus, Isabela Thais Machado de, Orlandi, Ariene Angelini dos Santos, Zazzetta, Marisa Silvana   +2 more
openaire   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Factors associated with social frailty in older adults in Colombia. [PDF]

J Frailty Aging
Curcio CL, Villada S, Chica L, Valencia CL.   +3 more
europepmc   +1 more source

Beyond Biomimetics: Pathology‐Informed Engineering Rescues Reconstituted HDL From Inflammatory Dysfunction for Sepsis Immunotherapy

Advanced Science, EarlyView.
A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou, Lei Zhang, Xingyu Cai, Jiajia Su, Guangyu Dai, Xue Chen, Hanming Wang, Jia Hua, Jianping Liu, Chunmeng Sun, Xiancheng Chen, Erhao Wang, Wenli Zhang   +12 more
wiley   +1 more source

‘Focus on Frailty’: Co-Designing Digital Frailty Education with Healthcare Students

Kristiana Ludlow,1,2 Sarah Martin,1,2 Benignus Logan,1,2 Ruth E Hubbard,1– 3 Nicola Warren,2,4,5 Olivia Gallagher,6,7 Bonnie K Kwok,1,8 Rosemary Saunders2,9 1Centre for Health Services Research, The University of Queensland, Woolloongabba, Queensland ...
Warren N, Kwok BK, Hubbard RE, Gallagher O, Saunders R, Ludlow K, Martin S, Logan B   +7 more
core  

SAT1‐Induced Spermidine Depletion Potentiates Food Allergy

Advanced Science, EarlyView.
Spermidine depletion, driven by upregulated spermidine/spermine N1‐acetyltransferase (SAT1), potentiates food allergy by promoting mast cell degranulation through autophagy suppression. SAT1 physically interacts with the long noncoding RNA Cdk19os to inhibit Atg5 and Atg7, disrupting autophagic flux.
Manman Liu, Beiyu Zhang, Junjuan Wang, Yue Jiang, Shiwen Han, Qianwei Wang, Lingyu Zeng, Jinfeng Wang, Huilian Che   +8 more
wiley   +1 more source