Results 51 to 60 of about 11,754,435 (295)

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Multi-Concept Frailty Predicts the Late-Life Occurrence of Cognitive Decline or Dementia: An Updated Systematic Review and Meta-Analysis of Longitudinal Studies

Frontiers in Aging Neuroscience, 2022
BackgroundFrailty is a multidimensional syndrome that increases an individual’s vulnerability for developing adverse health outcomes, which include dementia. It might serve as a promising target for dementia prevention.
Chun-Yan Guo, Zhen Sun, Chen-Chen Tan, Lan Tan, Wei Xu   +4 more
doaj   +1 more source

Ageing in Mexico : modelling health and frailty and its relationship to the use of health services and the supply of informal care [PDF]

Mexico is still a "young" country with pressing burdens on education, especially at secondary and high school levels, and high percentages of the population entering the work force each year. Yet, it will complete its "demographic transition" in the
Lopez-Ortega, Mariana
core   +1 more source

Predictive Abilities of the Frailty Phenotype and the Swiss Frailty Network and Repository Frailty Index for Non-Home Discharge and Functional Decline in Hospitalized Geriatric Patients [PDF]

, 2022
BACKGROUND: Frailty is increasingly applied as a measure to predict clinical outcomes, but data on the predictive abilities of frailty measures for non-home discharge and functional decline in acutely hospitalized geriatric patients are scarce ...
Schilling, N., Bertschi, D., Limacher, A., Stuck, Anna K., Bischoff-Ferrari, H. A., Gagesch, M.   +5 more
core   +2 more sources

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Mediating effect of social frailty on oral frailty and cognitive function in older adults: a cross-sectional study in a rural Chinese community

Frontiers in Aging Neuroscience
BackgroundCognitive function has been associated with both social and oral frailty. However, few studies have explored how social frailty and oral frailty jointly relate to cognitive function.
Zhiyue Jiang, Mei Wu, Ji Tang, Lingyao Xia, Jin Hu, Quanxiang Zhou, Xing Yang, Jingyuan Yang   +7 more
doaj   +1 more source

Associations between Driving Status, Frequency of Transport use after Driving Cessation, and Social Frailty among Middle-Aged and Older Adults [PDF]

Annals of Geriatric Medicine and Research
Background The use of transport other than cars is a modifiable factor in the association between driving cessation and social frailty. Clarifying this relationship may serve as a new preventive measure against social frailty among current non-drivers ...
Tatsuya Fukuei, Shoma Akaida, Yoshiaki Taniguchi, Daijo Shiratsuchi, Yuto Kiuchi, Mana Tateishi, Yukari Aishita, Ryota Kuratsu, Hyuma Makizako   +8 more
doaj   +1 more source

Social Frailty in Older People: A Concept Analysis. [PDF]

Rev Cuid
Introduction: Social frailty is a multidimensional concept that includes general and social resources, activities, and the fulfillment of needs; understanding and assessing it helps guide interventions for older adults. Objective: To clarify the concept of social frailty in older adults to improve its application in research, clinical practice, and ...
Rojas-Avila J, Araya AX, Pinilla Carrasco N.   +2 more
europepmc   +3 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Social factors associated with reversing frailty progression in community-dwelling late-stage elderly people: An observational study.

PLoS ONE, 2021
Frailty is considered to be a complex concept based mainly on physical vulnerability, but also vulnerabilities in mental/psychological and social aspects.
Katsuhiko Takatori, Daisuke Matsumoto
doaj   +1 more source