Results 41 to 50 of about 11,754,435 (295)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The association between social frailty, psychological resilience, and subsequent cognitive outcomes in older adults: A prospective cohort study

The Journal of Nutrition, Health and Aging
Background: The associations among social frailty, psychological resilience, and cognitive function, as well as their variations across sex and age, remain to be explored.
Yun-Jing Zhang, Cong Zhang, Qi-Yuan Lyu
doaj   +1 more source

Characterization of social frailty domains and related adverse health outcomes in the Asia-Pacific: a systematic literature review [PDF]

PeerJ
Background Frailty is a significant healthcare challenge worldwide, increasing interest in developing more assessment tools covering for frailty. Recently, there has been a growing awareness of a correlation between social variables and frailty in older ...
Tengku Aizan Hamid, Sarah Abdulkareem Salih, Siti Farra Zillah Abdullah, Rahimah Ibrahim, Aidalina Mahmud   +4 more
doaj   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

The Social Environment’s Relationship With Frailty: Evidence From Existing Studies [PDF]

Journal of Applied Gerontology, 2017
Increasingly, policymakers assume that informal networks will provide care for frail older people. While the literature has mainly discussed the role of the family, broader social networks are also considered to be important. However, these social networks can diminish in later life.
Duppen, Daan, Van der Elst, Michael C.J., Dury, Sarah, Lambotte, Deborah Françoise, De Donder, Liesbeth   +4 more
openaire   +3 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Social Vulnerability Predicts Frailty: Towards a Distinction between Fragility and Frailty?

The Journal of Frailty & Aging, 2022
All definitions of frailty converge in two aspects: the notion of loss or decline and the ability to predict negative health outcomes. Numerous factors were reported to be associated with frailty among which biological, psychological, economic and social factors.
H, Amieva, C, Ouvrard-Brouillou, J-F, Dartigues, K, Pérès, M, Tabue Teguo, A, Avila-Funes   +5 more
openaire   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

THE INFLUENCE OF LIFESTYLE BEHAVIORS ON THE INCIDENCE OF FRAILTY

, 2020
BACKGROUND: Frailty is a clinical state defined as an increase in an individual’s vulnerability to developing adverse health-related outcomes. OBJECTIVES: We propose that healthy behaviors could lower the incidence of frailty.
AVILA-FUNES, J.A., CANO-GUTIERREZ, C.A., BORDA, M.G., Avila-Funes, JA, Perez-Zepeda, MU, Gomez, RC, PÉREZ-ZEPEDA, M.U., Samper-Ternent, R, GÓMEZ, R.C., Cano-Gutierrez, CA, Borda, MG, SAMPER-TERNENT, R.   +11 more
core   +1 more source

Frailty in ethnic minority women

, 2021
In majority populations in high- and middle-income countries, women live longer yet experience higher levels of frailty than men of the same age. It is unclear whether this ‘sex–frailty paradox’ is present in ethnic minority populations.
Weerasekera, S, Reid, N, Gordon, EH, Hubbard, RE   +3 more
core   +1 more source