Results 91 to 100 of about 12,111,754 (350)

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

The “Worthless Stones” of Zincirli: Osman Hamdi Bey and the German Excavations of 1888–1902

open access: yesAnadolu Araştırmaları
This study investigates the archaeological excavations carried out by the German Orient-Comité at Zincirli Höyük between 1888 and 1902, using the Ottoman archives of the period and the documents in the Ottoman Imperial Museum.
Oğuz Satır, Ali Çifçi
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Hijazi migrations to Transjordan and their role in the political and social formation of the state (1922–1946)

open access: yesCogent Arts & Humanities
This article examines the migration of Hijazi clans to Transjordan and its formative influence on the emirate’s political and social structures during the early state-building period.
Ayman A. Mahamoud   +3 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

BLANKETS: a toasty tool to improve social history documentation for our older patients. [PDF]

open access: yesPostgrad Med J, 2022
Warner BE   +4 more
europepmc   +1 more source

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