Results 101 to 110 of about 2,906,069 (317)

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Beyond ethics to morality: Choices and relationships in bicultural research settings [PDF]

open access: yes, 2013
Knowledge of ourselves as cultural beings, of the values and beliefs of those with whom we work, and of the history of relations among those in our work settings are essential for community and applied social psychologists.
Furness, Jane Amanda   +3 more
core   +1 more source

Dragers van het vangnet. De publieke rol van Nederlandse sociale diensten (1980-1998)

open access: yesTijdschrift voor Sociale en Economische Geschiedenis, 2019
This article examines the public role of Dutch social service organizations during the 1980s and 1990s, amidst the so-called ‘crisis of the welfare state’. The story focuses on the association for directors of social service organizations, DIVOSA, which
Hans Rodenburg
doaj  

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

open access: yesMolecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci   +6 more
wiley   +1 more source

THE MAIN TENDENCIES OF PUBLIC MANAGEMENT REFORMS– FROM A HUNGARIAN POINT OF VIEW [PDF]

open access: yes
Over the course of human history each state decided on its own how broadly and how extensively to encroach on social conditions, i.e. which tasks to take on. However, the growth of state tasks and abstractions by the state (taxation) is a historical fact,
András TORMA
core  

Josephine Butler: women Rights between religion and military [PDF]

open access: yes, 2010
Tese de mestrado, Estudos Anglísticos, Universidade de Lisboa, Faculdade de Letras, 2009The following dissertation spots a light on social issues of women in the Victorian era. Intolerance was the main feature of victorian era.
Mdegish, Ainour Fathi
core  

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

open access: yesMolecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh   +8 more
wiley   +1 more source

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