Results 121 to 130 of about 589,700 (306)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Homelessness prediction models in high-income countries: a scoping review. [PDF]

BMC Public Health
Stängl LA, Baniunaite E, Fürstenau D, Schreiter S, Koh KA, Ito C, Marbin D.   +6 more
europepmc   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

The Evolutionary Psychology of Breaking Informal Versus Formal Contracts: Effects of Group Size and Area of Upbringing. [PDF]

Behav Sci (Basel)
Geher G, Eisenberg E, DeMaio M, Casa O, Caserta AJ, Cochran K, Cohen L, Dewan A, Dickinson-Frevola S, Fenigstein L, Giboyeaux C, Goren M, Jerabek E, Lieberstein J, Marr L, Staccio B, Tamayo N.   +16 more
europepmc   +1 more source

Knowledge Gap: History and Development

, 2016
C. Gaziano
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Depression and associated factors among patients with common eye diseases at the University of Gondar Comprehensive and Specialized Hospital Northwest Ethiopia. [PDF]

Discov Ment Health
Asfaw M, Kassew T, Tadele S, Fentahun S, Andualem F.   +4 more
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Mediating effects of psychological capital on the influencing relationship between social isolation and anxiety symptoms of maintenance hemodialysis patients. [PDF]

Front Psychol
Li Y, Yang F, Zhang J, Xiang M, Wu H.
europepmc   +1 more source

ADMINISTRATIVE AND LEGAL REGULATION OF THE SOCIAL, RECREATIONAL AND TOURIST SPHERE IN UKRAINE: HISTORY OF FORMATION AND CHALLENGES IN THE CONDITIONS OF MARTIAL LAW

B. B. Umantsiv
openalex   +1 more source