Results 71 to 80 of about 737,776 (266)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Relational identity and principle of solidarity as the bases for the intercultural education

Teoría de la Educación: Revista Interuniversitaria, 2014
Having established the failure of multiculturalism and all theoretical and practical alternatives for the study, analysis and management of social diversity and complexity, emerges the need to raise multiculturalism as the only logical alternative for ...
Nuria GARRO GIL, Sarah CARRICA OCHOA
doaj   +1 more source

An emergence perspective on entrepreneurship: processes, structure and methodology [PDF]

, 2008
This paper explores entrepreneurship from the perspective of emergence, drawing on literature in complexity theory, social theory and entrepreneurship.
Fuller, Ted, Warren, Lorraine, Welter, Friederike   +2 more
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The Weight of Emotions: Exploring How Young Activists Feel About Their Identity, Agency and Political Participation

Young
This article explores young people’s emotional associations with activism in relation to their social identity, sense of agency and activist participation.
Silvia Behrens
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Unfolding the layers of LGBTQ+ identity, resilience, and multicultural perspectives in Vietnam

Frontiers in Sociology
My personal narrative, intertwined with the theoretical acumen of Queer Theory and intersectionality framework, is used within this article as one way of underlining the critical role of lived experiences in forming an insight into LGBTQ+ identity and ...
Huy Lam-Nguyen
doaj   +1 more source

Islamic–Iranian Identity from the Perspective of Chaos and Complexity Theory [PDF]

جامعه شناسی کاربردی, 2014
Introduction In today's world having multiple identities, national, local, international, religious, occupational, gender, professional, group, tribal, linguistic and so on is a part of the requirements of social life. This paper seeks to investigate the
Sayed Vali Moosavinejad, Hamdallah Akvani   +1 more
doaj  

Polymorphic Students [PDF]

, 2016
Objective: In an effort to break away from the stale classifications of community college students that stem from the hegemonic perspective of previous literature, this work utilizes the perceptions of community college practitioners to demonstrate new ...
Levin, John S, López Damián, Ariadna Isabel, Morales Vazquez, Evelyn, Viggiano, Tiffany, Wolf, John-Paul   +4 more
core   +1 more source