Results 71 to 80 of about 5,031,134 (299)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Implementation of the Assistive Product List (APL) in Malawi through development of appropriate policy and systems: an action research protocol

BMJ Open, 2020
Introduction Assistive technology (AT) is important for the achievement of the sustainable development goals (SDGs) for persons with disabilities (PWD). Increasingly, studies suggest a significant gap between the need for and demand for and provisions of
Ikenna D Ebuenyi, Emma M Smith, Malcolm MacLachlan, Juba Kafumba, Monica Z Jamali, Alister Munthali   +5 more
doaj   +1 more source

Psychometric properties of the Adolescent Resilience Questionnaire (ARQ) in a sample of Swedish adolescents

BMC Psychiatry, 2022
Background The importance of resilience, and interest in it, has increased markedly in recent years, based on the need to understand why some children and young people have a resilience to stress that others lack.
Doris Nilsson, Carl Göran Svedin, Frida Hall, Emelie Kazemi, Örjan Dahlström   +4 more
doaj   +1 more source

Towards a social learning space for open educational resources [PDF]

, 2010
We identify a number of meanings of “Open”, as part of the motivating rationale for a social media space tuned for learning, called SocialLearn. We discuss why online social learning seems to be emerging so strongly at this point, explore features of ...
Buckingham Shum, Simon, Ferguson, Rebecca   +1 more
core  

Epistemic and social scripts in computer-supported collaborative learning [PDF]

, 2005
Collaborative learning in computer-supported learning environments typically means that learners work on tasks together, discussing their individual perspectives via text-based media or videoconferencing, and consequently acquire knowledge. Collaborative
A. Geyken, A. Hron, A. King, A. King, A. Weinberger, A. Weinberger, A.L. Brown, A.L. Veerman, A.M. O?Donnell, A.M. O?Donnell, A.S. Palincsar, B. Weiner, B.J. Reiser, B.K. Nastasi, C.A. Chinn, C.K.K. Chan, C.O. Larson, D. Clark, D.D. Suthers, D.D. Suthers, D.F. Dansereau, E.G. Cohen, F. Fischer, F.W. Hesse, G. Salomon, H. Mandl, I. Kollar, J. Piaget, J. Zhang, K. Hogan, L.R. Herrenkohl, L.W. Brooks, M. Baker, M. Scardamalia, M.T.H. Chi, N.M. Webb, N.M. Webb, P. Dillenbourg, R.J. Dufresne, S. Scarr, S. Teasley, V.I. Hytecker, W. Doise   +42 more
core   +6 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Agency Leaders' Assessments of Feasibility and Desirability of Implementation of Evidence-Based Practices in Youth-Serving Organizations Using the Stages of Implementation Completion

Frontiers in Public Health, 2018
Background: This study examined influences on the decisions of administrators of youth-serving organizations to initiate and proceed with implementation of an evidence-based practice (EBP).Methods: Semi-structured interviews, developed using the Stages ...
Lawrence A. Palinkas, Mark Campbell, Lisa Saldana   +2 more
doaj   +1 more source

Mental health problems among young people in substance abuse treatment in Sweden

Substance Abuse Treatment, Prevention, and Policy, 2020
Background Young people with substance use problems face a high risk of co-occurring mental health problems, something that may involve a more difficult life situation, social problems as well as worse treatment outcomes.
Torkel Richert, Mats Anderberg, Mikael Dahlberg   +2 more
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

SEL Is Adaptive: Exploring Implementation Integrity Through SEL Adaptations in OST Settings

Education Sciences
Although social emotional learning (SEL) is generally regarded as beneficial for children, there is an enduring tension between the need to observe fidelity to SEL programming (to reach desired outcomes) and the need to adapt SEL programming (to make ...
Natasha Raisch, Laura Stickle, Chelsea Rubin, Lillian Massaro, Cris Yanak-Cushman, Stephanie M. Jones, Rebecca Bailey   +6 more
doaj   +1 more source