Results 81 to 90 of about 1,009,104 (310)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

CONSIDERATION OF PAVEMENT TYPE SERVICE LIFE CAPACITY FOR SUSTAINABLE INFRASTRUCTURE DEVELOPMENT IN NIGERIA

open access: yesJournal of Construction Project Management and Innovation, 2019
The opposition over the use of concrete pavement against the conventional flexible pavement in Nigeria cannot be overemphasized; nevertheless, the question of interest should be: is concrete pavement now a way out of Nigeria road network? Certainly, the
Samuel Olugbenga Abejide   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Life cycle assessment of the sustainability of bridges: methodology, literature review and knowledge gaps

open access: yesFrontiers in Built Environment
Analysing the entire project life cycle is a new trend in sustainability assessment in the construction sector. Research on sustainability issues in the construction sector started with issues related to buildings, while research for other structures ...
Ivana Milić, Jelena Bleiziffer
doaj   +1 more source

Multicriteria decision-making method for sustainable site location of post-disaster temporary housing in urban areas [PDF]

open access: yes, 2016
Many people lose their homes around the world every year because of natural disasters, such as earthquakes, tsunamis, and hurricanes. In the aftermath of a natural disaster, the displaced people (DP) have to move to temporary housing (TH) and do not have
Fuente Antequera, Albert de la   +2 more
core   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Assessing sustainability performance of built projects: a building process approach [PDF]

open access: yes, 2010
Existing environmental performance assessment approaches focus on the overall performance to reflect sustainability of built projects. However, the impacts caused by construction activities on the environment occur throughout a project's life cycle which
Ding, GK, Shen, L
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Financial Reporting for Environmental and Social responsibility: A Normative Strategic Concept [PDF]

open access: yes
Corporate responsibility demands that firms address environmental and social values in their firm’s policy and key performance indicators. These are integrated through strategic planning and require firms to merge the longer term environmental and social
Jean Raar
core  

Education in 'life cycle sustainability assessment': caring for all 3 P's in one [PDF]

open access: yes, 2013
Starting from the observation that externalities, reflecting societal concerns, emerge from costs and benefits which are not reflected in the market price, the authors of the paper emphasize the importance in education of life cycle sustainability ...
Ciroth, Andreas   +3 more
core  

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