Results 81 to 90 of about 137,270 (302)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Life cycle assessment of the sustainability of bridges: methodology, literature review and knowledge gaps

Frontiers in Built Environment
Analysing the entire project life cycle is a new trend in sustainability assessment in the construction sector. Research on sustainability issues in the construction sector started with issues related to buildings, while research for other structures ...
Ivana Milić, Jelena Bleiziffer
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Investigating Life Cycle Cost, Environmental and Social Impacts of a Lithium–Ion Battery Pack

IEEE Open Journal of Vehicular Technology
This study evaluates the environmental, economic, and social impacts of the life cycle of a battery pack for automotive applications. The analysis employs Life Cycle Assessment (LCA) for environmental assessment, Life Cycle Costing (LCC) for economic ...
Antonella Accardo, Gaia Gentilucci, Luca Pontone, Ezio Spessa   +3 more
doaj   +1 more source

Social Life Cycle Assessment of Batteries

AbstractAs the demand for batteries is continuously increasing, understanding their social implications becomes increasingly important.This chapter points out the relevance of the social life cycle assessment (SLCA) to evaluate the effects on social issues of battery throughout its entire life cycle, from raw material extraction to disposal.In the ...
Maurizio Cellura, Anna Irene De Luca, Nathalie Iofrida, Marina Mistretta   +3 more
openaire   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Development of social sustainability assessment method and a comparative case study on assessing recycled construction materials

, 2017
© 2017, Springer-Verlag GmbH Germany. Purpose: Sustainability analysis should include the assessment of the environmental, social, and economic impacts throughout the life cycle of a product.
Chi Sun Poon, Ya Hong Dong, Hossain, Md Uzzal, Cheng, Jack C.P., Poon, Chi Sun, Dong, Ya Hong, Irene M. C. Lo, Jack C. P. Cheng, Lo, Irene M.C., Md. Uzzal Hossain   +9 more
core   +1 more source

Prospective life cycle sustainability assessment and benchmarking of hydrogen from solid oxide electrolysis coupled with concentrated solar power

Fuel Processing Technology
Achieving sustainable hydrogen systems requires balancing environmental, economic and social aspects. In this regard, research on the life-cycle sustainability of emerging pathways such as solid oxide electrolysis (SOE) coupled with concentrated solar ...
Mario Martín-Gamboa, Felipe Campos-Carriedo, Santiago Abelleira, Pedro L. Cruz, Christina Wulf, Javier Dufour, Diego Iribarren   +6 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Subcategory assessment method for social life cycle assessment. Part 2: application in Natura’s cocoa soap

, 2016
Purpose: The aim of this study is to test the Subcategory Assessment Method (SAM) by applying it to a real product (Natura’s cocoa soap). Methods: The case study was performed by first following the four phases of Social Life Cycle Assessment and by ...
Brones, Fabien, Ugaya, Cássia Maria Lie, Petti, Luigia, Sanchez Ramirez, Paola Karina   +3 more
core   +1 more source