Results 81 to 90 of about 1,015,661 (306)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

CONSIDERATION OF PAVEMENT TYPE SERVICE LIFE CAPACITY FOR SUSTAINABLE INFRASTRUCTURE DEVELOPMENT IN NIGERIA

Journal of Construction Project Management and Innovation, 2019
The opposition over the use of concrete pavement against the conventional flexible pavement in Nigeria cannot be overemphasized; nevertheless, the question of interest should be: is concrete pavement now a way out of Nigeria road network? Certainly, the
Samuel Olugbenga Abejide, Jacob Adebayo Adedeji, Moamed Mostafa   +2 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Life cycle assessment of the sustainability of bridges: methodology, literature review and knowledge gaps

Frontiers in Built Environment
Analysing the entire project life cycle is a new trend in sustainability assessment in the construction sector. Research on sustainability issues in the construction sector started with issues related to buildings, while research for other structures ...
Ivana Milić, Jelena Bleiziffer
doaj   +1 more source

Towards an overall framework to assess the sustainability of the use of natural resources [PDF]

, 2014
Over the years, the sustainable supply of natural resources for the global economy has drawn increasing political interest. The efficient use of resources is a fundamental issue for sustainability assessment, entailing and affecting environmental ...
Blengini, Gian Andrea, Dewulf, Jo, Mancini, Lucia, Pennington, David, Sala, Serenella   +4 more
core  

UNEP-SETAC guideline on global land use impact assessment on biodiversity and ecosystem services in LCA [PDF]

, 2013
Purpose As a consequence of the multi-functionality of land, the impact assessment of land use in Life Cycle Impact Assessment requires the modelling of several impact pathways covering biodiversity and ecosystem services.
Beck, Tabea, Brandão, Miguel, Civit, Bárbara María, De Baan, Laura, De Souza, Danielle Maia, Koellner, Thomas, Margni, Manuele, Milà i Canals, Llorenç, Müller Wenk, Ruedi, Saad, Rosie   +9 more
core   +3 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Investigating Life Cycle Cost, Environmental and Social Impacts of a Lithium–Ion Battery Pack

IEEE Open Journal of Vehicular Technology
This study evaluates the environmental, economic, and social impacts of the life cycle of a battery pack for automotive applications. The analysis employs Life Cycle Assessment (LCA) for environmental assessment, Life Cycle Costing (LCC) for economic ...
Antonella Accardo, Gaia Gentilucci, Luca Pontone, Ezio Spessa   +3 more
doaj   +1 more source

Financial Reporting for Environmental and Social responsibility: A Normative Strategic Concept [PDF]

Corporate responsibility demands that firms address environmental and social values in their firm’s policy and key performance indicators. These are integrated through strategic planning and require firms to merge the longer term environmental and social
Jean Raar
core