Results 81 to 90 of about 127,443 (255)

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Comparative Social Life Cycle Assessment of Two Biomass-to-Electricity Systems. [PDF]

open access: yesInt J Environ Res Public Health, 2021
Martín-Gamboa M   +3 more
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Which impacts matter for pavement management decisions? Quantifying social sustainability based on a capability approach

open access: yesTransportation Research Interdisciplinary Perspectives
This study addresses the need to evaluate the social sustainability of pavement management decisions, particularly during the use and maintenance stages.
Jessica Boakye, Egemen Okte
doaj   +1 more source

Locating Hotspots for the Social Life Cycle Assessment of Bio-Based Products from Short Rotation Coppice. [PDF]

open access: yesBioenergy Res, 2021
Fürtner D   +4 more
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Life Cycle Assessment and Model Optimization for Sustainable Energy Cross-Border E-Commerce

open access: yesEAI Endorsed Transactions on Energy Web
INTRODUCTION: In an in-depth study of the application of sustainable energy in cross-border e-commerce, a comprehensive assessment and model optimization of its life cycle are conducted to promote the practical application of sustainable development in ...
Hongli Liu, Ruiling Cui
doaj   +1 more source

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