Results 31 to 40 of about 2,050,463 (299)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Reactions to, and trial intentions for, three dissuasive cigarette designs: A cross-sectional survey of adolescents in Scotland

Tobacco Prevention and Cessation, 2020
Background The Scottish Government has identified dissuasive cigarettes, which provide exposure to health warnings at the point of consumption and reduce product attractiveness, as a future tobacco control measure to reduce smoking prevalence and ...
Danielle Mitchell, Nathan Critchlow, Crawford Moodie, Linda Bauld   +3 more
doaj   +1 more source

Market orientation practices of Ethiopian seed producer cooperatives

Humanities & Social Sciences Communications, 2023
The practices of market orientation are context-specific. This paper focuses on the concept and practices of market orientation in Ethiopian seed producer cooperatives (SPCs).
Dawit Tsegaye Sisay, Frans J. H. M. Verhees, Hans C. M. van Trijp   +2 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

A novel air quality feedback intervention trial using mHealth techniques across four European countries: the TackSHS Project Measuring for Change Study

Tobacco Prevention and Cessation, 2019
Introduction Second-hand tobacco smoke exposure is a cause of serious ill-health for children, and in most European countries this exposure occurs predominantly in the home. There is therefore a great deal of research interest in reducing smoking at home,
Esteve Fernandez, Ruaraidh Dobson, Rachell O’Donnell, Sean Semple, Marcela Fu, TackSHS Project Investigators   +5 more
doaj   +1 more source

Reactions to standardised cigarette packs with varying structural designs, and the association with smoking susceptibility: A post-implementation cross-sectional survey with never-smoking adolescents in Scotland

Tobacco Prevention and Cessation, 2020
Background From 20 May 2017, cigarettes in the United Kingdom must be sold in standardised (plain) packaging, however, in the UK cigarette packs are permitted to have varying shapes (e.g. bevelled-edges and slim) and opening methods (e.g.
Danielle Mitchell, Nathan Critchlow, Crawford Moodie, Linda Bauld   +3 more
doaj   +1 more source

Process and impact of implementing a smoke-free policy in prisons in Scotland: TIPs mixed-methods study

Public Health Research, 2022
Background: Prisons had partial exemption from the UK’s 2006/7 smoking bans in enclosed public spaces. They became one of the few workplaces with continuing exposure to second-hand smoke, given the high levels of smoking among people in custody.
Kate Hunt, Ashley Brown, Douglas Eadie, Nicola McMeekin, Kathleen Boyd, Linda Bauld, Philip Conaglen, Peter Craig, Evangelia Demou, Alastair Leyland, Jill Pell, Richard Purves, Emily Tweed, Tom Byrne, Ruaraidh Dobson, Lesley Graham, Danielle Mitchell, Rachel O’Donnell, Helen Sweeting, Sean Semple   +19 more
doaj   +1 more source

Market Socialism or Socialization of the Market?

New Left Review, 1988
This article criticizes the approaches of Ernest Mandel and Alee Nove. The author holds that there are alternatives to the market and bureaucratic planning. She says that the price mechanism is an essential instrument for the coordination of a socialist economy; but that the mechanism should itself be socialized so that it will work in favor of ...
openaire   +2 more sources

Social Media Marketing Integration: Agile Project Management [PDF]

, 2017
The implementation of digital and social media strategies to currently existing marketing strategies requires extensive knowledge and expertise. Project management techniques and practices can be utilized to implement this change and determine its ...
Holst, Ida M
core   +1 more source