Results 111 to 120 of about 28,076,424 (255)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Exploring loneliness and social media addiction: Key drivers of phubbing behaviour

In an age where digital communication dominates, smartphones have transformed human interaction, blurring the lines between personal and professional lives and creating a paradox; while technology fosters connectivity, it may also diminish authentic ...
Adzharuddin, Nor Azura, Bolong, Jusang, Kuppusamy, Elillarasi, Ahmad Zawawi, Siti Mazmi Niza   +3 more
core  

The Impact of Social Media Addiction on Life Satisfaction Mediated by the Fear of Missing Out Among Indonesian Youth [PDF]

openIndonesia is not exempt from the global trend of social media users increasing. The increasing number of social media users can be attributed to social media's good role as a tool for a person to retain social relationships with people while also ...
WIADNYANA, NI MADE PRATIWI
core  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

The mediating effect of social network identity management on the relationship between personality traits and social media addiction among pre-service teachers

BMC Psychology
Background The use of social media has become an important part individuals’ daily lives and is used in many daily life activities, such as social interaction, education, and shopping.
Onur Isbulan, Emre Cam, Mark D. Griffiths   +2 more
doaj   +1 more source

Impact of social media addiction on physical and mental health in medical and paramedical undergraduate students of Jamnagar urban area: A cross-sectional analytical study

National Journal of Physiology, Pharmacy and Pharmacology
Background: Sixty-three percent of the world population uses the Internet and 58% use social media. Internet addiction or social media addiction is an impulse disorder marked by excessive or poorly regulated pre-occupations, desires, or behaviors ...
Niketkumar Satapara, Samprada Tank, Arjun N Katariya, Jimmy Kagathara   +3 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Social Media Addiction: A Techno-centric View

, 2023
The current study take a techno-centric view and explore the role of technology in social media addiction from the affordance perspective. Drawing on the needs-affordances-features perspective and fit theory, we conceptualize the relationship between a ...
Zeng, Miaoyi, Armstrong, Deborah J
core