Results 101 to 110 of about 28,076,424 (255)

Social media addiction and depression among adolescents in two Malaysian states

International Journal of Adolescence and Youth
Addiction to social media addiction is considered a leading risk factor for depression among adolescents, but the relationship needs to be supported empirically. This study investigates the social media addiction level and its association with depression
Stephanie Ann Victor, Muhamad Shamsul Ibrahim, Sarina Yusuf, Norasyikin Mahmud, Khairul Azam Bahari, Loh Yoke Ling, Nur Nadia Abd Mubin   +6 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Investigation of the Risk of Social Media Addiction and Individual-Social Problems in Adolescents

Psikiyatride Güncel Yaklaşımlar
Objective: This study aimed to investigate the relationship between social media addiction and individual as well as social problems in adolescents. Method: A cross-sectional, relational design was employed from October 2020 to October 2021, involving ...
Damla Duman, Nazan Turan
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Addiction, Social Interactions and Gender Differences in Cigarette Consumption [PDF]

This paper addresses the impact of addiction and social interactions on cigarette demand, controlling for demographic and socioeconomic factors. A Box-Cox double-hurdle model for the simultaneous decisions of how much to smoke and whether to quit smoking
David Aristei, Luca Pieroni
core  

Domination and the arts of digital resistance in social media Creator labor [PDF]

This article conducts a collaborative qualitative thematic analysis of in-depth interviews with social media content creators (N = 53) based in and/or originated from the United Kingdom.
Saunders, Rebecca, Salamon, Errol
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The relationship between childhood psychological abuse and social media addiction among college students: the mediating role of fear of missing out and the moderating role of left-behind experience

Introduction Mobile social media is a new type of online media that is participatory, open, and communicative, among other characteristics. Due to the increasing popularity of social media, this technology has become an indispensable part of people’s ...
Hai-qin Yu, Peng-cheng Wei
core   +1 more source

A Person-Centered Approach to Social Media Addiction in Adolescents: Latent Profile Analysis of the Sense of Coherence, Cognitive Flexibility, and Emotion Regulation

Addicta: The Turkish Journal on Addictions
Social media addiction has become a widespread issue. Consequently, identifying the factors that mitigate social media addiction is of significant importance.
Bilal Kaya, Fulya Cenkseven Önder
doaj   +1 more source