Results 141 to 150 of about 1,502,953 (305)

XII Congreso Latinoamericano de Medicina Social y Salud Colectiva

, 2012
Association of Social Medicine, Latin American
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

More than just meds: National survey of providers’ perceptions of patients’ social, economic, environmental, and legal needs and their effect on emergency department utilization

Social Medicine, 2014
Introduction: Emergency departments (EDs) are the safety net for millions of patients who need to access care. Many of these patients have social needs that may influence their healthcare.
Lia ilona Losonczy, Dennis Hsieh, Chris Hahn, Jahan Fahimi, Harrison Alter   +4 more
doaj  

The role of social medicine in the COVID-19 pandemic era. [PDF]

J Glob Health, 2021
Bubbico L, Bellizzi S, Ferlito S, Cegolon L.   +3 more
europepmc   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Social Determinants of Health: Perspective of the ALAMES Social Determinants Working Group

Social Medicine
Introduction The recent discussion of the social determinants of health, which has been promoted by the WHO as a way to approach global health conditions is neither a new nor a foreign subject for Latin American social medicine or collective health ...
Oliva López Arellano, José Carlos Escudero, Luz Dary Camona   +2 more
doaj  

Shaking Off Our Lassitude: Creating a Global Health Service-Learning Program Founded in Social Medicine

Social Medicine, 2014
This paper describes the creation and implementation of a global health service-learning elective. The elective was supported by Brown University and Rhode Island Hospital.
Francis Xavier Coughlin
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

La Escuela de Salud Pública de México: su fundación y primera época, 1922-1945 The Mexican School of Public Health: its founding and first years: 1922-1945

Salud Pública de México, 2013
Este artículo reconstruye la historia fundacional de la Escuela de Salud Pública de México, inaugurada como Escuela de Salubridad en marzo de 1922.
María Rosa Gudiño-Cejudo, Laura Magaña-Valladares, Mauricio Hernández Ávila   +2 more
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source