Results 91 to 100 of about 13,352,161 (296)

Forging a Social Movement to Dismantle Entrenched Power and Liberate Primary Care as a Common Good. [PDF]

Ann Fam Med, 2023
Grumbach K.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Social movement organizing and the politics of emotion from HIV to Covid-19. [PDF]

Sociol Compass, 2022
Mackenzie S.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Efektivitas Kebijakan Sosial dalam Pemecahan Masalah Sosial

JSP: Jurnal Ilmu Sosial dan Ilmu Politik, 2011
Social policy was understood as a response of government toward social problems steam from individuals and systems, as well as social structures and social institutions.
- Soetomo
doaj   +1 more source

Exploring social movement concepts and actions in a knowledge uptake and sustainability context: A concept analysis. [PDF]

Int J Nurs Sci, 2022
Grinspun D, Wallace K, Li SA, McNeill S, Squires JE, Bujalance J, D'Arpino M, De Souza G, Farshait N, Gabbay J, Graham ID, Hutchinson A, Kinder K, Laur C, Mah T, Moore JE, Plant J, Ploquin J, Ruiter PJA, St-Germain D, Sills-Maerov M, Tao M, Titler M, Zhao J.   +23 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Mic Check! Media Cultures and the Occupy Movement

, 2019
Scholars and activists have hotly debated the relationship between social media and social movement activity during the current global cycle of protest.
Costanza-Chock, Sasha
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

The effect of breaking sitting time with physical activity breaks on cognitive performance in young people with cerebral palsy: an exposure response cross-over feasibility design

Translational Exercise Biomedicine
To assess the feasibility of methods and estimate the potential effect of interrupting sedentary behaviour, with intermittent or continuous physical activity breaks, on cognitive performance in young people with Cerebral Palsy.
Coe Shelly, Cossington Jo, Collett Johnny, Meaney Andy, Mavrommati Foteini, Ng Yujun, Izadi Hooshang, Wade Will, Pindus Dominika M., Bushnell Oliver, Whaymand Luke, Theologis Tim, Swift Emily, Akgul Ece, Allen Sam, Dawes Helen   +15 more
doaj   +1 more source