Results 111 to 120 of about 2,523,136 (241)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Effectiveness of exercise prehabilitation before anterior cruciate ligament reconstruction on functional outcomes – a single-blinded randomized controlled trial

open access: yesScientific Reports
Objective: To compare the effectiveness of an individually tailored, adaptive, guided, structured and criteria-based preoperative rehabilitation program (IG) to a structured, non-guided, self-administered home training program (CG) in individuals after ...
Rebecca Abel   +5 more
doaj   +1 more source

Community Versus Assimilation: A Study In American Assimilation at Saint Joseph\u27s Indian Industrial School [PDF]

open access: yes, 1997
No govemment policy has had more of an impact on American Indians than the boarding school movement of the early to mid-twentieth century. This movement isolated American Indian children from their homes and communities and attempted to assimilate them ...
Shillinger, Sarah
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Social Entrepreneurs by Chance: How environmentalists provide a favorable context for social entrepreneurial action. [PDF]

open access: yes, 2012
How, why, and under what conditions can social movements contribute to the development of social entrepreneurial process developed by embedded actors?
Groen, A.J.   +3 more
core   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

open access: yesMolecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor   +2 more
wiley   +1 more source

Conceptualising success and failure for social movements [PDF]

open access: yes, 2009
The paper discusses some of the most significant conceptions of success and failure present in the social movement literature, and highlights the gaps present in these theories.
Saeed, Raza
core  

Molecular cancer prevention: Intercepting disease

open access: yesMolecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco   +2 more
wiley   +1 more source

Transactions, Transformations, Translations: Metrics that Matter for Building, Scaling, and Funding Social Movements [PDF]

open access: yes, 2011
This report provides an evaluative framework and key milestones to gauge movement building. Aiming to bridge the gap between the field of community organizing that relies on the one-on-one epiphanies of leaders and the growing philanthropic emphasis on ...
Jennifer Ito   +2 more
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

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