Results 81 to 90 of about 12,421,734 (241)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Indigenous Social Movements in the Americas
Review of International American Studies, 2019 The present text serves as an introduction to RIAS Vol. 12, Spring–Summer № 1 /2019, dedicated to Indigenous social movements in the Americas. It outlines the major areas of interest of the Contributors, explaining ways in which the issue explores ...
Zuzanna Kruk-Buchowska, Jenny L. Davis
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Agroecological Formación in Rural Social Movements
Radical Teacher, 2014 Among the many sectors currently engaged in struggle against the corporate food system, small farmers play a particularly important role—not only do they constitute a legitimate alternative to global agribusiness, but also they are the heirs to long ...
Nils McCune, Juan Reardon, Peter Rosset
doaj +1 more source
Editorial: Socio-psychological perspectives on collective behavior and social movements. [PDF]
Front Psychol, 2023 Oyanedel JC +3 more
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
The effect of social movements on COVID-19 case increases and death in Turkey. [PDF]
Clin Epidemiol Glob Health, 2023 Gun MA, Hanci O.
europepmc +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
When social movements fail or succeed: social psychological consequences of a collective action's outcome. [PDF]
Front Psychol, 2023 Carvacho H +13 more
europepmc +1 more source