Results 141 to 150 of about 6,308,164 (355)

A survey of social cybersecurity: Techniques for attack detection, evaluations, challenges, and future prospects

open access: yesComputers in Human Behavior Reports
In today’s age of digital interconnectedness, understanding and addressing the nuances of social cybersecurity have become paramount. Unlike its broader counterparts, information security and cybersecurity, which are focused on safeguarding all forms of ...
Aos Mulahuwaish   +7 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

The Network of Innovators in Jena: An Application of Social Network Analysis [PDF]

open access: yes
We apply social network analysis methods to describe the evolution of the innovator network of Jena, Germany in the period from 1995 to 2001. We find this evolution to be directed towards an increasing focus on core competencies of the local innovation ...
Holger Graf, Uwe Cantner
core  

Network Topology Optimization Using Social Network Analysis

open access: yesJournal of Engineering and Sustainable Development, 2006
The topological design of networks in this work consists of finding a topology (directed and undirected links flow) that improve both the reliability index and increase the available shortest paths in the network without overloading the routing table or
Siddeeq Y. Ameen, Alaa N. Al-Qeicy
doaj  

Essays on Applied Network Theory. [PDF]

open access: yes
Network economics is a fast growing area of study, with a lot of potential for addressing a wide variety of socio-economic phenomena. Networks literally permeate our social and economic lives. The unemployed find jobs using the information and assistance
TETERYATNIKOVA, Mariya   +4 more
core  

NKCC1: A key regulator of glioblastoma progression

open access: yesMolecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen   +5 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

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