Results 131 to 140 of about 663,468 (311)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Computers in Human Behavior ReportsIn today’s age of digital interconnectedness, understanding and addressing the nuances of social cybersecurity have become paramount. Unlike its broader counterparts, information security and cybersecurity, which are focused on safeguarding all forms of ...
Aos Mulahuwaish +7 more
doaj +1 more source
Social Network Analysis of Mobile Streaming Networks
2016 17th IEEE International Conference on Mobile Data Management (MDM), 2016 Call data generated from mobile phones reflect a social network structure. Analyzing the topology, behavior and dynamics of such networks is one of the prevailing interests in network science. We propose to analyze call networks as a spatio-temporal evolutionary stream.
openaire +2 more sources
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The Analysis of Scientific Network of Italian Statisticians Combining Complementary Data Sources
, 2010 Scientific collaboration is a complex phenomenon characterized by an intense form of interaction among scientists improving the diffusion of knowledge in the scientific community.
DE STEFANO D. +5 more
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Internal Migration between US States - A Social Network Analysis [PDF]
In this paper we use the novel (at least in regional science) technique of social network analysis and apply it to one of the most analyzed topics in the discipline, US internal migration.
Gunther Maier, Michael Vyborny
core
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Network Topology Optimization Using Social Network Analysis
Journal of Engineering and Sustainable Development, 2006 The topological design of networks in this work consists of finding a topology (directed and undirected links flow) that improve both the reliability index and increase the available shortest paths in the network without overloading the routing table or
Siddeeq Y. Ameen, Alaa N. Al-Qeicy
doaj