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Fallibilism and Ontology in Tuukka Kaidesoja’s Critical Realist Social Ontology

Journal of Social Ontology, 2015
This article addresses Tuukka Kaidesoja’s critique of the philosophical presuppositions of Roy Bhaskar’s theories of critical realism. The article supports Kaidesoja’s naturalistic approach to the philosophy of the social sciences, including the field of
Little Daniel
doaj   +2 more sources

Demo: A community based approach for managing ontology alignments [PDF]

, 2008
The Semantic Web is rapidly becoming a defacto distributed repository for semantically represented data, thus leveraging on the added on value of the network effect.
Alani, Harith, Correndo, Gianluca, Kalfoglou, Yannis, Smart, Paul R   +3 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Time in the ontology of Cornelius Castoriadis [PDF]

, 2017
We can locate the problematic of time within three philosophical questions, which respectively designate three central areas of philosophical reflection and contemplation. These are: 1) The ontological question, i.e.
Schismenos, Alexandros
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Cambridge social ontology

Erasmus Journal for Philosophy and Economics, 2009
The Erasmus Journal for Philosophy and Economics is very pleased to present this interview with Tony Lawson in which he discusses his work on various issues including social ontology and critical realism in economics, along with the differences that he ...
Tony Lawson
doaj   +1 more source

Participatory design of a continuous care ontology : towards a user-driven ontology engineering methodology [PDF]

, 2011
The patient room of the future would be able to sense the needs and preferences of the patients and nurses and adapt itself accordingly by combining all the heterogeneous data offered by the different technologies. This goal can be achieved by developing
Ackaert, Ann, Bleumes, Lizzy, De Turck, Filip, De Zutter, Saar, Jacobs, An, Ongenae, Femke, Sulmon, Nicky, Van Gils, Mieke, Verhoeve, Piet, Verstraete, Mathijs   +9 more
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empathi: An ontology for Emergency Managing and Planning about Hazard Crisis

, 2018
In the domain of emergency management during hazard crises, having sufficient situational awareness information is critical. It requires capturing and integrating information from sources such as satellite images, local sensors and social media content ...
Gaur, Manas, Gyrard, Amelie, Shekarpour, Saeedeh, Sheth, Amit   +3 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Towards a social ontology of market systems [PDF]

, 2009
Academic analyses of market systems are deeply divided. While economists tend to neglect the personal and sociological factors that shape the behaviour of market actors, sociologists tend to discount the possibility of a systematic analysis of the ...
Elder-Vass, Dave
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