Results 31 to 40 of about 309,564 (337)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Lawson on Veblen on Social Ontology [PDF]

, 2015
This paper discusses Lawson’s use of Veblen’s concept of ‘neoclassical economics’ and argument that the category of neoclassical economics should be jettisoned on the grounds that it obfuscates effective critique of mainstream economics.
Davis, John B.
core   +1 more source

Actors and networks or agents and structures: towards a realist view of information systems [PDF]

, 2007
Actor-network theory (ANT) has achieved a measure of popularity in the analysis of information systems. This paper looks at ANT from the perspective of the social realism of Margaret Archer.
Alistair Mutch, Amsterdamska, O., Baumard, P., Bourdieu, P., Calhoun, C., Callinicos, A., Callinicos, A., Callinicos, A., Checkland, P., Ciborra, C., Collier, A., Collins, H.M., Currie, W., Dahlbom, B., Dennett, D.C., Edelman, G.M., Fowler, B., Fuller, S., Grint, K., Jones, M., Lakoff, G., Latour, B., Latour, B., Latour, B., Latour, B., Law, J., Law, J., Mutch, A., Norris, C., O'Brien, F., Roberts, R.H., Rose, H., Rose, H., Rose, S., Sayer, A., Searle, J.R., Singer, P., Sokal, A., Sokal, A.D., Walsham, G., Watson, T., Whitelegg, J., Whitley, R., Wilde, O.   +43 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Fallibilism and Ontology in Tuukka Kaidesoja’s Critical Realist Social Ontology

Journal of Social Ontology, 2015
This article addresses Tuukka Kaidesoja’s critique of the philosophical presuppositions of Roy Bhaskar’s theories of critical realism. The article supports Kaidesoja’s naturalistic approach to the philosophy of the social sciences, including the field of
Little Daniel
doaj   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Ontology of laughter: social-ethical aspects [PDF]

, 2018
Laughter is very important emotional manifestation for human being. The understanding of laughter’s nature and the determination of its main characters can’t be ignored because laughter is the ability that characterizes and determines the very human way ...
Stebelska, Olexandra
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

A community based approach for managing ontology alignments [PDF]

, 2008
The Semantic Web is rapidly becoming a defacto distributed repository for semantically represented data, thus leveraging on the added on value of the network effect.
Alani, Harith, Correndo, Gianluca, Smart, Paul R   +2 more
core   +1 more source

Time in the ontology of Cornelius Castoriadis [PDF]

, 2017
We can locate the problematic of time within three philosophical questions, which respectively designate three central areas of philosophical reflection and contemplation. These are: 1) The ontological question, i.e.
Schismenos, Alexandros
core   +1 more source