Results 41 to 50 of about 309,564 (337)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

empathi: An ontology for Emergency Managing and Planning about Hazard Crisis

open access: yes, 2018
In the domain of emergency management during hazard crises, having sufficient situational awareness information is critical. It requires capturing and integrating information from sources such as satellite images, local sensors and social media content ...
Gaur, Manas   +3 more
core   +1 more source

Materialising social ontology [PDF]

open access: yesCambridge Journal of Economics, 2017
Social theorists increasingly recognise that material things often play vital roles in the causation of social events. However there is substantial disagreement on how to theorise these roles. Several members of the Cambridge Social Ontology Group have made important contributions in the form of their work on the ontology of technological objects. This
openaire   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

The Concept of Gender Crossing in the Deirdre McCloskey’s Theory [PDF]

open access: yesJournal of Interdisciplinary Sciences, 2018
This article explores the concept of gender identity of the famous American economist Deirdre McCloskey. The concept has three key elements: Firstly, gender identity does not directly refer to sexual orientation.
Khitruk Ekaterina
doaj  

Demo: A community based approach for managing ontology alignments [PDF]

open access: yes, 2008
The Semantic Web is rapidly becoming a defacto distributed repository for semantically represented data, thus leveraging on the added on value of the network effect.
Alani, Harith   +3 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

On the Nature of Social and Institutional Reality [PDF]

open access: yes, 2001
What is the nature of the social reality? How do the major social institutions like money or law exist? What are the limits of individualistically-oriented social theories?These and related problems are intensely discussed in philosophy, in legal theory ...
Ikäheimo, Heikki   +2 more
core  

A Holistic Social Constructionist perspective to Enterprise Education [PDF]

open access: yes, 2015
Purpose – Drawing on the Gestalt approach this article proposes a holistic framework for enterprise education (EE) research based on Social Constructionism, illustrating how the latter supports research into experiential learning in EE in 7 UK Higher ...
Deema Refai   +3 more
core   +1 more source

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