Results 41 to 50 of about 46,456 (291)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Fallibilism and Ontology in Tuukka Kaidesoja’s Critical Realist Social Ontology
Journal of Social Ontology, 2015 This article addresses Tuukka Kaidesoja’s critique of the philosophical presuppositions of Roy Bhaskar’s theories of critical realism. The article supports Kaidesoja’s naturalistic approach to the philosophy of the social sciences, including the field of
Little Daniel
doaj +2 more sources
Social Space and the Ontology of Recognition [PDF]
, 2011 In this paper recognition is taken to be a question of social ontology, regarding the very constitution of the social space of interaction. I concentrate on the question of whether certain aspects of the theory of recognition can be translated into the ...
Italo Testa, Testa, Italo
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Erasmus Journal for Philosophy and Economics, 2009 The Erasmus Journal for Philosophy and Economics is very pleased to present this interview with Tony Lawson in which he discusses his work on various issues including social ontology and critical realism in economics, along with the differences that he ...
Tony Lawson
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Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Two approaches to naturalistic social ontology
, 2023 Social ontological inquiry has been pursued in analytic philosophy as well as in the social scientific tradition of critical realism. These traditions have remained largely separate despite partly overlapping concerns and similar underlying strategies of
Sarkia, Matti, Kaidesoja, Tuukka
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
The Concept of Gender Crossing in the Deirdre McCloskey’s Theory [PDF]
Journal of Interdisciplinary Sciences, 2018 This article explores the concept of gender identity of the famous American economist Deirdre McCloskey. The concept has three key elements: Firstly, gender identity does not directly refer to sexual orientation.
Khitruk Ekaterina
doaj