Results 71 to 80 of about 7,916,499 (329)
On ‘common-sense ontology’:A comment on the paper by Frank Hindriks and Francesco Guala [PDF]
, 2015 This note comments on Hindriks and Guala’s ‘unified theory of institutions’. One of the components that Hindriks and Guala seek to unify, and which they claim is unsatisfactory on its own, is the analysis of conventions that derives from the work of ...
Hume +6 more
core +1 more source
Causal powers and social ontology
Synthese, 2018 Over the last few decades, philosophers and social scientists have applied the so-called powers ontology to the social domain. I argue that this application is highly problematic: many of the alleged powers in the social realm violate the intrinsicality ...
Tobias Hansson Wahlberg
semanticscholar +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
(WP 2015-03) Lawson on Veblen on Social Ontology [PDF]
, 2015 This paper discusses Lawson’s use of Veblen’s concept of ‘neoclassical economics’ and argument that the category of neoclassical economics should be jettisoned on the grounds that it obfuscates effective critique of mainstream economics.
Davis, John B.
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Ontology, methodological individualism, and the foundations of the social sciences [PDF]
, 2016 This is a review essay, based on a critical assessment of The Ant Trap by Brian Epstein. Epstein argues that models in the social sciences are inadequate because they are based on a false ontology of methodological individualism, and proposes a new model
Mäki Uskali, Robert Sugden
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Studia Semiotyczne, 2020 DOI: http://doi.org/10.26333/sts.xxxiv1.11 This paper reassesses the criticism of the Lucas-Penrose anti-mechanist argument, based on Gödel’s incompleteness theorems, as formulated by Krajewski (2020): this argument only works with the additional ...
Paula Quinon
doaj
Lawson on Veblen on Social Ontology [PDF]
, 2015 This paper discusses Lawson’s use of Veblen’s concept of ‘neoclassical economics’ and argument that the category of neoclassical economics should be jettisoned on the grounds that it obfuscates effective critique of mainstream economics.
Davis, John B.
core +1 more source