Results 101 to 110 of about 3,883,150 (311)

Gender, Social Capital and Collective Action: A gender perspective on collective sustainability of water resource governance in west Nepal [PDF]

, 2019
In Nepal, as in other South Asian countries, water resource development is often considered to be a primarily technological challenge, requiring engineered solutions.
Clement, Floriane, Shrestha, Gitta
core  

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

The Role of Families in Shaping Youth Social Participation: Evidence from Singapore [PDF]

Youth participation in social groups is important in developing skills and experience for successful transition to adulthood. What kinds of families do youth who are active in social groups and who take on leadership positions come from?
Irene Y.H. Ng, K.C. Ho, Kong Weng Ho
core  

Studying Paths of Participation in Viral Diffusion Process

, 2012
Authors propose a conceptual model of participation in viral diffusion process composed of four stages: awareness, infection, engagement and action. To verify the model it has been applied and studied in the virtual social chat environment settings.
A. Bruyn De, A. Keenan, A. Nowak, A.. Bandura, B. Latané, C. Bulte van den, C. Bulte van den, C. Shu-Chuan, D. Godes, D.J. Watts, D.J. Watts, E. Bakshy, E.M. Rogers, G.J. Golan, H.C. Chiu, J. Arndt, J. Coleman, J. Goldenberg, J.Y.C. Ho, L. Festinger, M. Granovetter, M. McPherson, M. Trusov, N.A. Christakis, N.A. Christakis, R. Lans van der, R. Thackeray, S. Goel, T.W. Valente   +28 more
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Association between Hypometabolism in the Supplementary Motor Area and Fear of Falling in Older Adults

Frontiers in Aging Neuroscience, 2017
Background: A better understanding of the neural mechanisms that underlie the development of fear of falling (FoF) in seniors may help to detect potential treatable factors and reduce future falls. We therefore investigate the neural correlates of FoF in
Ryota Sakurai, Ryota Sakurai, Ryota Sakurai, Ryota Sakurai, Yoshinori Fujiwara, Masashi Yasunaga, Hiroyuki Suzuki, Kazuyuki Kanosue, Manuel Montero-Odasso, Kenji Ishii   +9 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

DETERMINANTS OF COMMUNITY PARTICIPATION IN ORADEA [PDF]

The present paper is part of the research of the PhD thesis made by the author, having the title: Community Participation in Oradea, registered at the University of Oradea - Faculty of Social and Human Sciences.
SAVEANU TOMINA GABRIELA
core  

Social Justice in the EU – Index Report 2016 Social Inclusion Monitor Europe [PDF]

, 2016
1. Social justice in the EU – participation opportunities have improved in the majority of EU member states, but are still a long way behind precrisis levels Social justice has improved slightly in the majority of EU member states compared with last ...
Schiller, Christof, Schraad-Tischler, Daniel   +1 more
core  

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source