Results 71 to 80 of about 1,248,042 (313)

A Prospective Audit Investigating How the Anticholinergic Effect of Medications on Cognition Is Assessed and Reduced in Patients Admitted to an Older Adult Ward in a Psychiatric Hospital

BJPsych Open
Aims: Older adults often have multiple comorbidities associated with an increased risk of anticholinergic effects. Mental health medications increase this risk, contributing to cognitive decline, dementia, memory loss and confusion.
Dinushi Marambe, Prami Rai
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Supporting Non-Psychiatric Trainees to Engage with Reflective Practice and Attend to Their Wellbeing Through Balint Group

BJPsych Open
Aims: Doctors in training report high rates of burnout. The Balint group lends itself to addressing emotional stress and hence the associated risk of burnout. However, Balint group attendance among GP trainees and foundation doctors locally has been poor
Ayatalla Gabre, Elinor Bradley
doaj   +1 more source

Problem statement of modeling the congruence of social partnership participants' interests based on agency approach [PDF]

, 2015
The article deals with the peculiarities of institutional regulation of social and labor relations in the country by using the multi agent approach. All members of labor market have been presented as economic agent.
Sybirtsev, Volodymyr, Сибірцев, В. В.   +1 more
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Local status and power in area-based health improvement partnerships [PDF]

, 2014
This is the authors' PDF version of an article published in Health© 2014. The definitive version is available at http://hea.sagepub.comArea-based initiatives (ABIs) have formed an important part of public policy towards more socio-economically deprived ...
Bartlett D, Berkeley D, Bradford N, Carlisle S, Charmaz K, Department for Communities and Local Government, Department of Health, Department of Health, Elias N, Elias N, Elias N, Elias N, Elias N, Elias N, Lawless P, National Institute for Health and Clinical Excellence, Pawson R, Stewart M, Strauss AL, Unwin J, Yin RK   +20 more
core   +4 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Evaluating the impact of the report "Faithful Cities" on the Church of England's role in urban regeneration: case study in two Dioceses (Birmingham and Worcester) [PDF]

, 2011
The Church of England's approach to urban regeneration has been shaped by government-led regeneration and its own social, political and financial situation, rather than its theology.
Atfield, Tom David
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Introducing the Dementia Crisis Service in East Kent: Can We Reduce Rates of Hospital Admission?

BJPsych Open
Aims Admissions to hospital can be traumatic for a person with dementia due to an inability to cope with unfamiliar environments, faces and routines.
Swarupa SriBalaskanda, Bastiaan Veugelers   +1 more
doaj   +1 more source

Social partnership in the system of social and labour relations of the hotel and restaurant economy [PDF]

, 2017
У статті розглянуто поняття соціального партнерства в системі соціально-трудових відносин готельно-ресторанного господарства. Розглянуті форми соціального партнерства. Розкриті принципи соціального партнерства.
Фальченко, Олена Олександрівна
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