Results 91 to 100 of about 77,843 (256)

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

open access: yesMolecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh   +6 more
wiley   +1 more source

Flattery Harm in Social Interactions and its Pathology from Imam Ali’s Viewpoint

open access: yesپژوهش در دین و سلامت, 2019
For downloading the full-text of this article please click here. Background and Objective: The issue of flattery and its individual and social consequences are regarded as a moral vice in many human societies and the higher degree of this trait in the ...
Omid Ebrahimi   +2 more
doaj  

A Randomized Controlled Trial of a Play-Based, Peer-Mediated Pragmatic Language Intervention for Children With Autism

open access: yesFrontiers in Psychology, 2019
PurposeThis randomized controlled trial evaluated the effectiveness of a play-based pragmatic language intervention for children with autism.MethodsA sample of 71 children with autism were randomized to an intervention-first group (n = 28 analyzed) or ...
Lauren Parsons   +6 more
doaj   +1 more source

Selfsupervised learning for pathological speech detection [PDF]

open access: yesarXiv
Speech production is a complex phenomenon, wherein the brain orchestrates a sequence of processes involving thought processing, motor planning, and the execution of articulatory movements. However, this intricate execution of various processes is susceptible to influence and disruption by various neurodegenerative pathological speech disorders, such as
arxiv  

\$1 Today or \$2 Tomorrow? The Answer is in Your Facebook Likes [PDF]

open access: yesarXiv, 2017
In economics and psychology, delay discounting is often used to characterize how individuals choose between a smaller immediate reward and a larger delayed reward. People with higher delay discounting rate (DDR) often choose smaller but more immediate rewards (a "today person").
arxiv  

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi   +26 more
wiley   +1 more source

Using Contextual Information to Improve Blood Glucose Prediction [PDF]

open access: yesarXiv, 2019
Blood glucose value prediction is an important task in diabetes management. While it is reported that glucose concentration is sensitive to social context such as mood, physical activity, stress, diet, alongside the influence of diabetes pathologies, we need more research on data and methodologies to incorporate and evaluate signals about such temporal
arxiv  

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

open access: yesMolecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam   +9 more
wiley   +1 more source

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