Results 111 to 120 of about 78,466 (309)
Mechanically Triggered DNA Nanovehicles for Targeted Dual‐Drug Cancer Therapy
Advanced Science, EarlyView.A mechanically triggered DNA nanovehicle is introduced that co‐releases two anticancer drugs in response to integrin‐mediated cellular forces. Cholesterol‐anchored DNA assemblies undergo force‐induced unfolding at cell–cell junctions, enabling selective, localized dual‐drug activation in cancer cells while minimizing off‐target toxicity in low‐tension ...
Murali Mohana Rao Singuru +2 more
wiley +1 more source
Advanced Science, EarlyView.SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang +33 more
wiley +1 more source
Changing practice and values? An exploration of social pedagogy for a Council’s Children's Services Workers [PDF]
, 2020 Social pedagogy is a conceptual framework which takes both an educational and social perspective to addressing social problems, and is embedded within the children’s services and wider social workforce in many European countries. By contrast, England and
Chavaudra, Nicole
core
PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression
Advanced Science, EarlyView.Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian +13 more
wiley +1 more source
Social Ostracism and Bullying Among Social Pedagogy and Pedagogy-Psychology Students
Emerging Science JournalThis study examines the impact of social ostracism and bullying among students of social pedagogy, pedagogy, and psychology, while identifying differences in their coping strategies. Using a mixed-methods approach, 66 students (aged 17–22) were surveyed with the Need Threat Scale (NTS-O) to assess ostracism, the SACS questionnaire to analyze coping ...
Indira Shaikhymuratova +5 more
openaire +2 more sources
Preventive interventions in socio-pedagogical social work
, 2017 Artikel behandlar socialpedagogiska angreppssätt för preventiva sociala insatser inom socialt arbeteGlobal economic, cultural and ideological process in society affect social work and the Welfare regimes in developed countries.
Dychawy Rosner, Irena +1 more
core
, 2022 Ethnographic studies are characterised by the researchers’ active pursuit to create a variation in the empirical material, which is necessary to discern and subsequently analyse social phenomena.
Basic, Goran, Yakhlef, Sophia
core
Lessons From Drug Discovery for Cryoprotective Agent Design: An AI‐Oriented Perspective
Advanced Science, EarlyView.Cryoprotectant design is reframed through the lens of drug discovery as a multiparameter optimization problem. This perspective highlights how AI and systematic design strategies could enable safer, more effective cryoprotectants, while identifying key limitations that currently constrain predictive progress in cryobiology. ABSTRACT Cryopreservation is
Dominika Wilczok +4 more
wiley +1 more source
Intercompany training as production pedagogical process
Вестник Самарского государственного технического университета. Серия: Психолого-педагогические науки, 2016 The article explains the corporate training as a coordinated interaction of educational and industrial processes in the preparation of in-demand professionals.
Evgeny A. Korchagin +2 more
doaj
Social pedagogy and social work [PDF]
Hungarian Educational Research Journal, 2022 openaire +1 more source