Results 201 to 210 of about 947,113 (263)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

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Social presence in telemedicine

Journal of Telemedicine and Telecare, 2002
We studied consultations between a doctor, emergency nurse practitioners (ENPs) and their patients in a minor accident and treatment service (MATS). In the conventional consultations, all three people were located at the main hospital. In the teleconsultations, the doctor was located in a hospital 6 km away from the MATS and used a videoconferencing ...
Sapal, Tachakra, Rakhi, Rajani
openaire   +2 more sources

From Online Social Presence to Network Social Presence

2014
Open Network Learning Environment (ONLE) empowers network learners to create, edit, and share their knowledge via social network connection. This chapter examines the predictive relationship between social presence and ONLE interaction and scrutinizes the relationships between social presence and four dimensions of ONLE's interaction.
Chih-Hsiung Tu, Cherng-Jyh Yen, Michael Blocher, Junn-Yih Chan   +3 more
openaire   +1 more source

Social Presence

2014
Over the years, the advance of technology has changed the ways of instructions in higher education, and new communication trends as well as innovative pedagogy evolved to be reconciled with new technology trends in distance education. What are the major challenges of communication in distance education?
Libi Shen, Irene Linlin Chen
openaire   +1 more source

The evolution of conventions in the presence of social competition

Games and Economic Behavior, 2022
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Ennio Bilancini, Leonardo Boncinelli
openaire   +2 more sources

Social presence with virtual glass

2015 IEEE Virtual Reality (VR), 2015
Collaborative Virtual Environments (CVE) with co-located or remote video communication functionality require a continuous experience of social presence. If, at any stage during the experience the communication interrupts presence, then the CVE experience as a whole is affected — spatial presence is then decoupled from social presence.
Holger Regenbrecht, Mansoor Alghamdi, Simon Hoermann, Tobias Langlotz, M. Goodwin, Colin Aldridge   +5 more
openaire   +1 more source

Social Presence in Digital Community

2018 International Symposium on Agent, Multi-Agent Systems and Robotics (ISAMSR), 2018
Digital community is the current trend in knowledge economy, where knowledge is shared and sought after by people in community over the Internet and the cloud, yet it is not limited to only teaching and learning institutions. The need for social presence is becoming more important for a person with knowledge, hence the idea of embedding software agents
Shahrinaz Ismail, Siti Haryani Shaikh Ali   +1 more
openaire   +1 more source