Results 91 to 100 of about 430,868 (306)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Derechos sociales y la libertad de establecimiento y prestación de servicios

Revista Vasca de Administración Pública, 2010
The rules about freedom of establishment and services provision have the purpose to remove barriers to carry out an important number of economic activities.
José Ignacio Cubero Marcos
doaj   +1 more source

Challenges of migration for the social pedagogy in Swedish context

, 2016
The key aspects to how the Swedish social insurance system is implemented are a high degree of universalism and the promotion of equality. The aim of this article is to explore certain issues of complexity in recent societal changes, in order to ...
Dychawy Rosner, Irena
core  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Social prescribing of cultural opportunities to support health and wellbeing: the importance of language, community engagement, and inclusion in developing local approaches

BMC Primary Care
Background There is growing evidence for the role of culture in supporting health and wellbeing, including as part of social prescribing provision. This study set out to explore the existing cultural provision and mechanisms for connecting people to ...
Anna Dadswell, Hilary Bungay
doaj   +1 more source

Профилактические мероприятия для социально незащищенной группы населения г. Алматы

Актуальные проблемы теоретической и клинической медицины, 2022
This article describes the creation of a day care center for the elderly and the provision of medical and social rehabilitation with common therapeutic diseases such as arterial hypertension and cognitive disorders. The paper shows the possibilities of a
А. Т. Маншарипова, А. К. Ешманова, Г. М. Ералиева, Г. В. Шокарева, Б. Ж. Аубакиров, А. И. Нуфтиева, А. Е. Тулеужанова, С. К. Бисенов, Р. Кумар, С. Джитендра, М. Прощенко, Ш. Автахунов   +11 more
doaj  

Discrimination in the provision of social services to the poor: a field experimental study [PDF]

We use an experimental field approach to understand better the pro-social preferences andbehavior of both individuals involved in the provision of social services (public servants) and the behavior of those potential beneficiaries, the poor. We conducted
Juan Camilo Cárdenas, Alejandro Gaviria, Sandra Polania, Natalia Candelo   +3 more
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source