Results 71 to 80 of about 430,868 (306)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Greening Red Vienna: lessons for social-ecological housing provision
Sustainability: Science, Practice, & PolicyContemporary housing systems neither live up to their social nor their ecological aims, resulting in affordability and environmental crises. We explore the potentials for securing access to affordable and adequate housing for all while rapidly reducing ...
Andreas Novy +4 more
doaj +1 more source
Social provisions in patients with mitochondrial diseases
BMJ Neurology OpenBackground Mitochondrial diseases often follow a chronic, multimorbid disease course in adults. Like other chronic conditions, mitochondrial diseases present a challenge to public and community health models and patients are potentially at higher risk of social isolation and loneliness.
Sameen Haque +5 more
openaire +3 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
, 2019 This chapter sets out the processes and outcomes of the involvement of a group of service users and carers in the provision of social work education at the School of Health and Social Work University of Hertfordshire, England.
LINKS GROUP, CREATING
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Aspekti Publìčnogo Upravlìnnâ, 2014 An analysis of scientific conceptions on public administration mechanism’s enhancement in the field of medical-resort provision for children in Ukraine is presented in the article.
T. Y. Kovalenko
doaj
Corporate social responsibility in public health provision: Community members’ assessment
Cogent Medicine, 2019 Mining companies often deliver various health interventions for respective mining enclaves yet, majority of these services often apply a top-down approach with limited community involvement.
Williams Agyemang-Duah +6 more
doaj +1 more source