Results 101 to 110 of about 2,068,129 (355)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Профилактические мероприятия для социально незащищенной группы населения г. Алматы

Актуальные проблемы теоретической и клинической медицины, 2022
This article describes the creation of a day care center for the elderly and the provision of medical and social rehabilitation with common therapeutic diseases such as arterial hypertension and cognitive disorders. The paper shows the possibilities of a
А. Т. Маншарипова, А. К. Ешманова, Г. М. Ералиева, Г. В. Шокарева, Б. Ж. Аубакиров, А. И. Нуфтиева, А. Е. Тулеужанова, С. К. Бисенов, Р. Кумар, С. Джитендра, М. Прощенко, Ш. Автахунов   +11 more
doaj  

Urban development and transport disadvantage: Methodology to evaluate social transport needs in Latin American cities [PDF]

This article examines the theoretical framework for accessibility, social exclusion and provision of public transport. The socio-economic and urban characteristics of Latin American cities require the creation of specific indices to determine social ...
Alejandro L. Grindlay, Carmen Lizarraga, Ciro Jaramillo   +2 more
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Performance Rating and Yardstick Competition in Social Service Provision [PDF]

This paper investigates whether national evaluation of decentralised government performance tends, by lessening local information spill-overs, to reduce the scope for local performance comparisons and consequently to lower the extent of spatial auto ...
Federico Revelli
core  

European Union Pension Directive [PDF]

, 2003
[Excerpt] This Directive thus represents a first step on the way to an internal market for occupational retirement provision organised on a European scale. By setting the ‘prudent person’ rule as the underlying principle for capital investment and making
The European Parliament and the Council of the European Union
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Social prescribing of cultural opportunities to support health and wellbeing: the importance of language, community engagement, and inclusion in developing local approaches

BMC Primary Care
Background There is growing evidence for the role of culture in supporting health and wellbeing, including as part of social prescribing provision. This study set out to explore the existing cultural provision and mechanisms for connecting people to ...
Anna Dadswell, Hilary Bungay
doaj   +1 more source

Derechos sociales y la libertad de establecimiento y prestación de servicios

Revista Vasca de Administración Pública, 2010
The rules about freedom of establishment and services provision have the purpose to remove barriers to carry out an important number of economic activities.
José Ignacio Cubero Marcos
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source