Results 91 to 100 of about 3,526,779 (312)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Human Rights in the Heartland: An Assessment of Social, Economic, Civil, and Political Rights in the Midwest [PDF]

, 2005
This report measures human rights progress in the heart of the United States. In this compilation, eight Midwestern states are evaluated on a freedom index, providing a comparative snapshot of local commitments to civil, political, social, and economic ...
Amy Rynell, Curtis Jones
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

From industrial to digital citizenship: rethinking social rights in cyberspace. [PDF]

Theory Soc, 2023
Tomasello F.
europepmc   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

[Is information on social rights accessible to cancer patients?] [PDF]

Cad Saude Publica, 2023
Batista FG, Szklo AS.
europepmc   +1 more source

Human Rights Accountability Through Treaty Bodies: Examining Human Rights Treaty Monitoring for Water and Sanitation [PDF]

, 2015
Framing scholarship on human rights accountability through treaty bodies, this article examines the water and sanitation content of state human rights reporting to the United Nations Committee on Economic, Social and Cultural Rights.
Kim, Yuna, Meier, Benjamin Mason
core   +1 more source

'Caught Between a Rock and a Hard Place': Anti-discrimination Legislation in the Liberal State and the Fate of the Australian Disability Discrimination Act [PDF]

, 2002
This article offers a critical analysis of some of the practical implications for disabled people of the Disability Discrimination Act of 1992. Specifically, it raises questions about politics and the role of the law as an instrument of social change ...
ACROD, ACROD, Attridge M., Banks R., Barnes C., Barry N., CAA [Community Aid Abroad], Cabassi J., Charlesworth H., Gooding C., Graham H.D., Greenwood G., Howe B., HREOC [Human Rights and Equal Opportunity Commission], HREOC [Human Rights and Equal Opportunity Commission], HREOC [Human Rights and Equal Opportunity Commission], HREOC [Human Rights and Equal Opportunity Commission], Jones M., Jones M., Kanter A.S., Laski H., Mackimon C., Maddox G., Mason A., Menzies R., Mosley A., NSWADB [New South Wales Anti-Discrimination Board], NSWADB [New South Wales Anti-Discrimination Board], Pengelly K., Peter Handley, Riker W., Thornton M., UPIAS [Union of the Physically Impaired against Segregation], Yeatman A.   +33 more
core   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

The Relevance of the Concept of the Social Market Economy: Concluding Observations on the Contributions in this Special Issue

Utrecht Law Review, 2019
This article discusses the contributions of this Special Issue on the relationship between social and economic values and rights. It shows that the contributions are illustrative of the various ways in which the social market economy concept is, and ...
Frans Pennings
doaj   +1 more source