Results 91 to 100 of about 7,989,963 (307)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Pracownik i pracodawca – wykorzystanie technik projekcyjnych w badaniu postrzegania wzajemnych relacji

open access: yesProblemy Zarządzania, 2014
The aim of this paper is to analyze a perception of employer and employee social role (Goffman, 1959) by diverse social groups (Kostera, 2012) and its consequences for the psychological contract which is a significant relationship factor in working ...
Anna Pawłowska, Agnieszka Postuła
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Measures to ensure and support the realization of the «Third Mission» of the university under martial law and post-war reconstruction

open access: yesУніверситети і лідерство
Today, the issue of cooperation and involvement of universities in solving social problems of communities is a strategically important task, and Ukrainian universities should take on the role of leaders of change and socio-economic development.
Nadiia Vasynova
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Student’s Attitudes to Parenthood and the Social Roles of Men and Women

open access: yesСоциологическая наука и социальная практика, 2019
The article analyzes the attitudes of young men and women based on a study of 1408 undergraduates of specialists in various fields of training at the age of 20–24 years, which held at the end of 2018 in Moscow and Stavropol.
Tatiana A. Gurko
doaj   +1 more source

Social Functioning of Children and Their Parents: Are They Related? [PDF]

open access: yes, 2010
This study examined whether parents' social support was related to their children's peer acceptance and likability. The moderating role of the parent's and the child's gender was also examined.
Wetzel, Megan
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

SOCIAL CONFLICTS IN CHARITIES: REASONS, CONSEQUENCE SAND WAYS OF SOLVING THEM

open access: yesВестник университета, 2017
The article deals with the origin of social conflicts of international charities by addressing to a science of conflictology, it also emphasizes the difference between egoism and altruism related motivation of the parties involved into a charity process;
O. Andrienko
doaj  

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