Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
A General Case Study of Complexity Science: Analytical and Logical Interconnection Between Soft and Hard Sciences (Invited Paper) [PDF]
Journal of Systemics, Cybernetics and Informatics, 2018 Complexity science is gaining popularity due to its unique approach to address convoluted and multi-dimentional problems. In this work, we present a general case study of complexity science by means of analytical and logical interconnection between soft ...
Jack Jia-Sheng Huang, Yu-Heng Jan
doaj
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Classifications of Sociological Paradigms
EncyclopediaIn this entry paper, we propose a brief analysis of the use of the notion of “paradigm” in sciences in general and in social sciences and sociology in particular.
Alexandru-Cosmin Apostol, Romeo Asiminei
doaj +1 more source
On the history and use of some standard statistical models
, 2008 This paper tries to tell the story of the general linear model, which saw the light of day 200 years ago, and the assumptions underlying it. We distinguish three principal stages (ignoring earlier more isolated instances). The model was first proposed in
Lehmann, E. L.
core +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Social Sciences and „The Nation’s Science”. Some considerations
Sfera Politicii, 2013 This article focuses on the contributions of the Monographic School members to social sciences in Romania of the interwar period. The main theories and methodologies configured and applied by these scientists are presented in broader, comparative ...
Alina Branda
doaj
Survey of Theory-building Barriers in Social Sciences Area [PDF]
مدیریت بازرگانی, 2009 Social Sciences with such topics as human behavior, groups and communities, and in general deal with human and social systems. These subjects are very dynamic and variable, and form in complex interactions network.
Ali Asghar Pour Ezzat +2 more
doaj
Understanding the work of general practitioners: a social science perspective on the context of medical decision making in primary care [PDF]
, 2008 Robert Geneau +3 more
openalex +1 more source
The herd moves? Emergence and self-organization in collective actors? [PDF]
The puzzle about collective actors is in the focus of this contribution. The first section enters into the question of the adequateness and inadequateness of reductionist explanations for the description of entities.
Martin Beckenkamp
core