Results 111 to 120 of about 2,110,914 (308)

THE IMPORTANCE OF THE SOCIAL SCIENCES IN THE UPBRINGING OF A HARMONIOUS GENERATION

open access: yes, 2023
This article will provide information about the pedagogical approach to taking history lessons, the main tasks of raising a free-minded young generation in the 21st century. In critical and free fiction, the role of history lessons in the Social Sciences is highlighted.
openaire   +2 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice

open access: yesAnnals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022
Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls   +9 more
wiley   +1 more source

Germline variants in CDKN2A wild‐type melanoma prone families

open access: yesMolecular Oncology, EarlyView.
Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen   +5 more
wiley   +1 more source

Social Sciences and „The Nation’s Science”. Some considerations

open access: yesSfera Politicii, 2013
This article focuses on the contributions of the Monographic School members to social sciences in Romania of the interwar period. The main theories and methodologies configured and applied by these scientists are presented in broader, comparative ...
Alina Branda
doaj  

A General Case Study of Complexity Science: Analytical and Logical Interconnection Between Soft and Hard Sciences (Invited Paper) [PDF]

open access: yesJournal of Systemics, Cybernetics and Informatics, 2018
Complexity science is gaining popularity due to its unique approach to address convoluted and multi-dimentional problems. In this work, we present a general case study of complexity science by means of analytical and logical interconnection between soft ...
Jack Jia-Sheng Huang, Yu-Heng Jan
doaj  

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Social diversity for reducing the impact of information cascades on social learning [PDF]

open access: yesarXiv, 2018
Collective behavior in online social media and networks is known to be capable of generating non-intuitive dynamics associated with crowd wisdom and herd behaviour. Even though these topics have been well-studied in social science, the explosive growth of Internet computing and e-commerce makes urgent to understand their effects within the digital ...
arxiv  

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