Results 111 to 120 of about 395,948 (290)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

A Storm in an IoT Cup: The Emergence of Cyber-Physical Social Machines

open access: yes, 2018
The concept of social machines is increasingly being used to characterise various socio-cognitive spaces on the Web. Social machines are human collectives using networked digital technology which initiate real-world processes and activities including ...
Creese, Sadie   +5 more
core  

Information diffusion in social sensing

open access: yesNumerical Algebra, Control and Optimization, 2016
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Krishnamurthy, Vikram, Hoiles, William
openaire   +2 more sources

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

open access: yesFEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Revealing the City Influence and Its Pattern Using Web Search Data: A New Perspective Through Attention Flow

open access: yesISPRS International Journal of Geo-Information
City influence is a critical topic in regional studies, reflecting how cities draw attention and exert impact in various domains. Understanding city influence is essential for fostering sustainable urban growth.
Xiaoxiao Wang   +6 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

From tweets to energy trends (TwEn2): social sensing–informed urban building energy modeling

open access: yesFrontiers in Energy Research
This study builds on our previous research, “From Tweets to Energy Trends (TwEn)” framework, which demonstrated the potential of social media interactions to inform urban energy predictions through a data-driven approach.
Narjes Abbasabadi, Mehdi Ashayeri
doaj   +1 more source

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