Results 81 to 90 of about 13,885,691 (303)
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Journal of Artificial Societies and Social Simulation, 2017 The research field of social simulation comprises many topics and research directions. A previous study about the early years indicated that the community has evolved into a differentiated discipline.
Jonas Hauke, Iris Lorscheid, M. Meyer
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Political Research ExchangePolicy assessment is often limited to the evaluation of the physical effectiveness or economic efficiency. To analyse how policies intervene in the complex reality, qualitative and quantitative complex system modelling approaches from the field of ...
Christoph Schünemann +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
Advancing the art of simulation in the social sciences [PDF]
Complexity, 1997 Advancing the state of the art of simulation in the social sciences requires appreciating the unique value of simulation as a third way of doing science, in contrast to both induction and deduction. This essay offers advice for doing simulation research, focusing on the programming of a simulation model, analyzing the results and sharing the results ...
openaire +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
SOCIAL IMPACT ASSESSMENT BY SOCIAL SIMULATION [PDF]
Impact Assessment, 1986 ABSTRACT Social simulation is a methodology, in which real social interaction is generated under simulated conditions, representing the reference system. Models have been developed for production organizations, science policy advisory councils and governmental bureaucracies.
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