Results 51 to 60 of about 593,251 (264)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Adaptation of traditional children's games to social studies course

Cypriot Journal of Educational Sciences, 2020
One of the greatest goals of the 21st century is the acquisition of high-level skills through the STEM course designs to provide skill-assisted transformation in learning processes. The purpose of this research; The aim of this course is to examine the views of teachers about STEM course designs supported by traditional Turkish games adapted to primary
Seval Orak, Adem Çilek, Ferah Güçlü Yilmaz   +2 more
openaire   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

An Action Research on Basic Competence in Science and Technology in Social Studies Course

Anadolu Üniversitesi Eğitim Fakültesi dergisi
Social Studies course is one of the basic courses that prepare students for social life. Change and development have become important in science and technology in the present time.
Fatih Pala
doaj   +1 more source

SOSYAL BİLGİLER ÖĞRETMENLERİNİN SAVAŞ ve BARIŞ KAVRAMLARININ ÖĞRETİMİNE İLİŞKİN GÖRÜŞLERİ

Turkish History Education Journal, 2017
Bu araştırmanın temel amacı, sosyal bilgiler öğretmenlerinin derslerinde savaş ve barış kavramlarının öğretimine ilişkin görüşlerini ortaya koymaktır. Araştırma, nitel araştırma yöntemlerinden fenomonolojik desene uygun olarak yürütülmüştür. Araştırmanın
Fatih ÖZDEMİR, Hülya ÇELİK
doaj   +1 more source

How Do the Teachers Define Social Studies Course?

Journal of Education and e-Learning Research, 2017
In this research, the aim is to determine what the social studies teachers think about the interdisciplinary structure of the social studies course and the educational situation. Likert type questionnaire and semi-structured interview form were used as data collection tools.
openaire   +1 more source

Social Studies Student Teachers’ Views on “School Experience Course”

International Journal of Education and Literacy Studies, 2020
This study sought to determine the opinions of prospective teachers studying in the last year of the social studies undergraduate program about the school experience. More specifically, it was aimed to determine the views of social studies preservice teachers concerning the necessity of the school experience course, the contribution of the course to ...
Burcu Kaymak, Nadire Emel Akhan
openaire   +2 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Interdisciplinary island studies: connecting the social sciences, natural sciences and humanities [PDF]

Island Studies Journal, 2016
In this paper, we present the outline of an interdisciplinary undergraduate course entitled: “Islands: Models for our Planet – Metaphors for our World”, and will reflect on insights gained during its development and teaching in two consecutive academic ...
Sietze J. Norder, Kenneth F. Rijsdijk
doaj