Results 71 to 80 of about 654,954 (312)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

The biology of inequalities in health: the LIFEPATH project [PDF]

, 2017
Socioeconomic differences in health have been consistently observed worldwide. Physical health deteriorates more rapidly with age among men and women with lower socioeconomic status (SES) than among those with higher SES.
Avendano-Pabon,, Maurico, Vineis, Paolo, Giuseppe Costa, Fraga, S, Cathal McCrory, Layte, Richard, Carmeli, C, Mika Kivimaki, Giles, G, Silvia Polidoro, Delpierre, C, Lang, T, Marmot, Michael, Milne, Roger L., Marcel Goldberg, Giles, Graham, Chadeau-Hyam, Marc, D'Errico, Angelo, D'Errico, A, Graham Giles, McCrory, Cathal, Cristian Carmeli, Michelle Kelly-Irving, Barros, H, Polidoro, S, Ricceri, Fulvio, Silvia Fraga, Ricceri, F, Peter Muennig, Lang, Thierry, Goldberg, M, Dijmarescu, Michaela, Barros, Henrique, Fraga, Silvia, Michaela Dijmarescu, Robinson, O, Kelly-Irving, Michelle, Avendano-Pabon, M, Thierry Lang, Oliver Robinson, Maurico Avendano-Pabon,, Delpierre, Cyrille, Zins, Marie, Henrique Barros, Goldberg, Marcel, Costa, G (Giuseppe), Milne, Roger, Kivimaki, Mika, Angelo D'Errico, Muennig, P, Marc Chadeau-Hyam, Mackenbach, Johan P, Dijmarescu, M, D’Errico, Angelo, Avendano-Pabon, Mauricio, Stringhini, Silvia, Roger Milne, Michael Marmot, Milne, Roger L, Johan Mackenbach, Marie Zins, Richard Layte, Silvia Stringhini, Costa, Giuseppe, Kelly-Irving, M, Fulvio Ricceri, Mackenbach, Johan, Zins, M, Wilma Nusselder, Layte, R, Robinson, Oliver, Cyrille Delpierre, Muennig, Peter, Carmeli, Cristian, Nusselder, Wilma, Kivimaki, M, Vineis, P, McCrory, C, Mackenbach, Johan P., Stringhini, S, Marmot, M, Paolo Vineis, Polidoro, Silvia, Chadeau-Hyam, M, Milne, RL   +84 more
core   +1 more source

An Action Research on Basic Competence in Science and Technology in Social Studies Course

Anadolu Üniversitesi Eğitim Fakültesi dergisi
Social Studies course is one of the basic courses that prepare students for social life. Change and development have become important in science and technology in the present time.
Fatih Pala
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Exploring COVID-19 in a social studies methods course: Preservice teachers harness the current pandemic to design inquiry-based WebQuests for elementary learners

, 2020
COVID-19 quickly upended life in many ways, presenting teachers with the opportunity to confront the issue with their students or forge ahead in the midst of a societal crisis.
Piedmont, Erin Vaughn
core  

Sosyal bilgiler dersi öğretim programındaki becerilerin 7. sınıf sosyal bilgiler ders kitabında yer alan etkinlikler kapsamında incelenmesi [PDF]

, 2019
Bu araştırmanın amacı sosyal bilgiler dersi öğretim programındaki beceriler ile 7. sınıf sosyal bilgiler ders kitabındaki etkinliklerin uyumunun incelenmesidir.
Avcı, Görkem, Akyol, Canan, Dikicigil, Özdemir, Gümüş, Nevzat   +3 more
core  

Reading Autobiographies, Memoirs, and Fictional Accounts in the Classroom: Is it Social Studies?

, 2003
Two professors share ideas regarding connections between autobiography, memoir, fiction, and social studies curriculum. The authors outline two narrative approaches they employed in their social studies curriculum and instruction courses for pre-service ...
Schick, Carol, Hurren, Wanda
core   +1 more source

Towards a health-enabling working environment - developing and testing interventions to decrease HIV and TB stigma among healthcare workers in the Free State, South Africa: study protocol for a randomised controlled trial

Trials, 2018
Background Occupational exposure to tuberculosis (TB) constitutes a major health risk for healthcare workers (HCWs). The HIV epidemic equally affects the workforce because of the mutually reinforcing epidemiology of HIV and TB.
Asta Rau, Edwin Wouters, Michelle Engelbrecht, Caroline Masquillier, Kerry Uebel, Gladys Kigozi, Nina Sommerland, André Janse van Rensburg   +7 more
doaj   +1 more source