Results 101 to 110 of about 28,121,044 (303)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
TEMPORAL CHARACTERISTICS AND CONTRADICTIONS OF STUDENT YOUTH
Высшее образование в России, 2016 Student youth is considered as a specific age community. Its development has inherent temporal characteristics and complex temporal contradictions.
Polina A. Ambarova, Garold E. Zborovsky
doaj
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Killing (Life)Time: A study on the Experience of Time in Prision
Sortuz, 2015 Prison emerged in its early forms in Europe in the mid 16th century and it spread together with capitalism. It operates by imposing to the individual a particular rigid time regime in an extremely limited spatial environment.
Pablo Leandro Ciocchini
doaj
Private and social time preference for health outcomes: A general population survey in Iran. [PDF]
PLoS One, 2019 Mahboub-Ahari A +4 more
europepmc +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Sociologies, 2013 We wanted to determine to what extent the time prescribed for legal work could be reconciled with family life and its temporality, especially in the context of large law firms.
Diane-Gabrielle Tremblay +1 more
doaj
A Functional NIRS Study of Brain Functional Networks Induced by Social Time Coordination. [PDF]
Brain Sci, 2019 Mizuno M, Hiroyasu T, Hiwa S.
europepmc +1 more source