Results 121 to 130 of about 1,819,903 (248)
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Assessing Children’s Access to Speech Therapy Services During the COVID-19 Pandemic: A Qualitative Study [PDF]
Journal of RehabilitationObjective Given the global emergence of the COVID-19 pandemic, notably in Iran, implementing preventive measures and protocols has constrained the accessibility of rehabilitation services, such as speech therapy.
Marzieh Takaffoli +5 more
doaj
Improving the Performance of the European Social Model - The Welfare State over the Life Cycle [PDF]
The achievements of social-welfare arrangements in Western Europe are well known: considerable income security, relatively little poverty and, in some countries, ample supply of social services.
Lindbeck, Assar
core
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Investigating the Requirements for Integration of the Social Determinants of Health Approach in Rehabilitation Education: A Qualitative Study in Iran [PDF]
Journal of RehabilitationObjective Studies have examined social accountability in medical education in Iran, while no studies have deeply focused on social determinants of health, specifically for rehabilitation sciences.
Meroe Vameghi +4 more
doaj
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
An Essay on Welfare State Dynamics [PDF]
The expansion of welfare-state arrangements is seen as the result of dynamic interaction between market behaviour and political behaviour, often with considerable time lags, sometimes generating either virtuous or vicious circles.
Lindbeck, Assar
core
Sustainable bioplastics manufacturing from renewable sources
FEBS Open Bio, EarlyView.Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
The determinants of social spending in Spain (1880-1960): Is Lindert right? [PDF]
The main objective of this paper is to analyse the origins of the welfare state in Spain using the theoretical framework designed by Peter Lindert.
Margarita Vilar Rodriguez +1 more
core +1 more source