Mutant glycyl-tRNA synthetase (Gars) ameliorates SOD1G93A motor neuron degeneration phenotype but has little affect on Loa dynein heavy chain mutant mice [PDF]
, 2009 Background: In humans, mutations in the enzyme glycyl-tRNA synthetase (GARS) cause motor and sensory axon loss in the peripheral nervous system, and clinical phenotypes ranging from Charcot-Marie-Tooth neuropathy to a severe infantile form of spinal ...
Antoni L. Andreu +8 more
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Investigation of the Role of Zn/Cu Index and its Correlation with Physiological Activity of SOD 1 and GRx in Males with Acne Vulgaris [PDF]
Archives of Razi Institute, 2022 It has been approved that the normal physiology of skin can be adversely affected by acne vulgaris (AV). This disorder leads to impairment of stratum corneum hydration and causes trans epidermal water loss.
H. H Naji +3 more
doaj +1 more source
Effects of Combine Exercise on HSP70 and SOD1 Expression of Aorta, Skeletal Muscle and Myocardium in High Fat Diet induced Obese Aging Rats [PDF]
운동과학, 2020 PURPOSE Exercise improve myocardial cell protection and vascular function through cell repair and suppression of oxidative stress in cardiovascular diseases caused by aging. This study aimed to investigate the effect of combine exercise on HSP70 and SOD1
Nayoung Ahn
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Medical Journal of Babylon, 2022 Background: Polycystic ovarian syndrome (PCOS) is an endocrinopathy disorder that affects women worldwide and is linked to an etiological factor as well as pathophysiology.
Aghras Sabah Nawar +2 more
doaj +1 more source
Arhiv za Higijenu Rada i Toksikologiju, 2022 This study aimed to investigate the effect of 150 mg/L sodium fluoride (NaF) on redox status parameters and essential metals [copper (Cu), iron (Fe), and zinc (Zn)] in the blood, liver, kidney, brain, and spleen of Wistar rats and to determine the ...
Radovanović Jelena +12 more
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Synaptic actions of amyotrophic-lateral-sclerosis-associated G85R-SOD1 in the squid giant synapse [PDF]
, 2020 © The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Song, Y.
Song, Yuyu
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Motor Neuron Generation from iPSCs from Identical Twins Discordant for Amyotrophic Lateral Sclerosis
Cells, 2020 Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder characterized by the loss of the upper and lower motor neurons. Approximately 10% of cases are caused by specific mutations in known genes, with the remaining cases having no ...
Emily R. Seminary +10 more
doaj +1 more source
Copper Ions and Parkinson’s Disease: Why Is Homeostasis So Relevant?
Biomolecules, 2020 The involvement of copper in numerous physiological processes makes this metal ion essential for human life. Alterations in copper homeostasis might have deleterious consequences, and several neurodegenerative disorders, including Parkinson’s ...
Marco Bisaglia, Luigi Bubacco
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Biomarkers and molecular mechanisms of Amyotrophic Lateral Sclerosis
AIMS Neuroscience, 2022 Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in adults involving non-demyelinating motor disorders. About 90% of ALS cases are sporadic, while 10–12% of cases are due to some genetic reasons.
Ashok Chakraborty, Anil Diwan
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Amyotrophic lateral sclerosis and intestinal microbiota—toward establishing cause and effect
Gut Microbes, 2020 The intestinal microbiota may be involved, through metabolic gut–brain interactions, in a variety of neurological conditions. In this addendum, we summarize the findings of our recent study investigating the potentially modulatory influence of the ...
Marc Gotkine +2 more
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