Results 101 to 110 of about 74,541 (281)

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Modification of superoxide dismutase 1 (SOD1) properties by a GFP tag--implications for research into amyotrophic lateral sclerosis (ALS).

PLoS ONE, 2010
BackgroundSince the discovery that mutations in the enzyme SOD1 are causative in human amyotrophic lateral sclerosis (ALS), many strategies have been employed to elucidate the toxic properties of this ubiquitously expressed mutant protein, including the ...
James C Stevens, Ruth Chia, William T Hendriks, Virginie Bros-Facer, Jan van Minnen, Joanne E Martin, Graham S Jackson, Linda Greensmith, Giampietro Schiavo, Elizabeth M C Fisher   +9 more
doaj   +1 more source

Evaluation of Acute Exposure to Combustible and Novel Tobacco Products Using an In Vitro Human Airway Organ Tissue Equivalent Model

Journal of Applied Toxicology, EarlyView.
ABSTRACT Despite the well‐known risks of tobacco use, tobacco exposure remains a major contributor to morbidity and mortality worldwide. Although cigarette use has declined, the popularity of novel tobacco products (NTPs), such as electronic cigarettes (ECs) and heated tobacco products (HTPs), has increased.
Timothy S. Leach, Steven Albertson, Phillip W. Clapp, Vikram Surendran, Trang Simon, Eric C. Donny, Stephen J. Walker, Anthony Atala, Sean V. Murphy   +8 more
wiley   +1 more source

Redox environment is an intracellular factor to operate distinct pathways for aggregation of Cu,Zn-superoxide dismutase in amyotrophic lateral sclerosis

Frontiers in Cellular Neuroscience, 2013
Dominant mutations in Cu,Zn-superoxide dismutase (SOD1) cause a familial form of amyotrophic lateral sclerosis (fALS). Misfolding and aggregation of mutant SOD1 proteins are a pathological hallmark of SOD1-related fALS cases; however, the molecular ...
Yoshiaki eFurukawa
doaj   +1 more source

Nanostructured lipid carriers and natural deep eutectic solvents: a highly advantageous combination for the encapsulation of curcumin

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Curcumin is a naturally derived polyphenol known for its potent biological properties. Its therapeutic potential, however, is hindered by low bioavailability. Nanostructured lipid carriers (NLCs) have emerged as advanced delivery systems to overcome such limitations. Natural deep eutectic solvents (NADESs) have garnered attention as
Kyriaki Safari, Ioanna Pitterou, Marianthi Miliaronikolaki, Nikolaos Paraskevopoulos, Andromachi Tzani, Anastasia Detsi   +5 more
wiley   +1 more source

Spinal cord homogenates from SOD1 familial amyotrophic lateral sclerosis induce SOD1 aggregation in living cells.

PLoS ONE, 2017
Mutant Cu/Zn superoxide dismutase (SOD1) can confer its misfolding on wild-type SOD1 in living cells; the propagation of misfolding can also be transmitted between cells in vitro.
Edward Pokrishevsky, Ran Ha Hong, Ian R Mackenzie, Neil R Cashman   +3 more
doaj   +1 more source

Chrysanthemum morifolium extract protects HT22 cells from oxidative stress and enhances sleep via GABAergic modulation: contribution of luteolin‐7‐glucoside

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Chrysanthemum morifolium has long been utilized in traditional medicine for its antioxidant and sedative properties, yet its potential in sleep regulation and neuroprotection against oxidative stress remains underexplored. This study investigates the antioxidant and sleep‐enhancing effects of C.
Hyeongyeong Kim, Seok Hyun Chung, Singeun Kim, Sooil Ko, Jae‐Chul Jung, Hyun Jung Lee, Hyowon Lee   +6 more
wiley   +1 more source

Chronic Stress Enhances Hepatotoxic Effects of Sorbic and Benzoic Acids in a Rat Model [PDF]

Journal of Stress Physiology & Biochemistry
Background: The individual effects of psychological stress and food preservatives on the liver—the body’s primary detoxification organ—are well-documented; however, little is known about their combined impact.
D.O. Karimov, Yu.V. Ryabova, E.F. Repina, Ya.V. Valova, A.A. Gizatullina, T.G. Yakupova, D. A. Smolyankin, O.A. Khmel, M.V. Kurilov   +8 more
doaj  

Specific analysis of SOD1 enzymatic activity in CSF from ALS patients with and without SOD1 mutations

Neurobiology of Disease
Mutations in superoxide dismutase-1 (SOD1) are a cause of hereditary amyotrophic lateral sclerosis (ALS) through a gain-of-function mechanism involving unfolded mutant SOD1.
Laura Leykam, Karin M.E. Forsberg, Ulrika Nordström, Karin Hjertkvist, Agneta Öberg, Eva Jonsson, Peter M. Andersen, Stefan L. Marklund, Per Zetterström   +8 more
doaj   +1 more source

Screening of drugs inhibiting in vitro oligomerization of Cu/Zn-superoxide dismutase with a mutation causing amyotrophic lateral sclerosis

Frontiers in Molecular Biosciences, 2016
Dominant mutations in Cu/Zn-superoxide dismutase (SOD1) gene have been shown to cause a familial form of amyotrophic lateral sclerosis (SOD1-ALS). A major pathological hallmark of this disease is abnormal accumulation of mutant SOD1 oligomers in the ...
Itsuki Anzai, Keisuke Toichi, Eiichi Tokuda, Atsushi Mukaiyama, Atsushi Mukaiyama, Shuji Akiyama, Shuji Akiyama, Yoshiaki Furukawa   +7 more
doaj   +1 more source