Results 121 to 130 of about 74,541 (281)

Expression of human superoxide dismutase (SOD) 1 G93A and chlorovirus ATCV-1 SOD increases the response of macrophages to inflammatory stimulants, including ATCV-1 major capsid protein glycans

Immunobiology
One cause of familial Amyotrophic Lateral Sclerosis (ALS) is a mutation in Super Oxide Dismutase 1 (SOD1) whereby amino acid 93 is alanine instead of glycine (SOD1-G93A).
Thomas M. Petro, Ahmed Esmael, Gary L. Pattee, Fiyad Al-Sarmi, Fabrizio Chiodo, Irina V. Agarkova, David D. Dunigan, James L. Van Etten   +7 more
doaj   +1 more source

Diminished GAD67 Terminals and Ambient GABA Inhibition Associated with Reduced Motor Neuron Recruitment Threshold in the SOD1 ^G93A ALS mouse [PDF]

, 2021
Sharmila Venugopal, Zohal Ghulam-Jhelani, Dwayne D. Simmons, Scott H. Chandler   +3 more
openalex   +1 more source

Upregulation of sphingomyelin and ABCA8 in response to TDP‐43 pathology in amyotrophic lateral sclerosis brain

Brain Pathology, EarlyView.
Increases in sphingomyelin in response to TDP‐43 pathology in the disease‐affected motor cortex of amyotrophic lateral sclerosis (ALS) brain. Abstract Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease characterized by the degeneration of motor neurons and the presence of TAR DNA‐binding protein 43 (TDP‐43 ...
Finula I. Isik, Russell Pickford, Nicolas Dzamko, Kerry‐Anne Rye, Woojin Scott Kim   +4 more
wiley   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Molecular chaperone mediated late-stage neuroprotection in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

PLoS ONE, 2013
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the selective loss of motor neurons in the spinal cord, brain stem, and motor cortex. Mutations in superoxide dismutase (SOD1) are associated with familial ALS and
Sergey S Novoselov, Wendy J Mustill, Anna L Gray, James R Dick, Naheed Kanuga, Bernadett Kalmar, Linda Greensmith, Michael E Cheetham   +7 more
doaj   +1 more source

Copper–zinc superoxide dismutase (Sod1) activation terminates interaction between its copper chaperone (Ccs) and the cytosolic metal-binding domain of the copper importer Ctr1 [PDF]

, 2019
Amélie Skopp, Stefanie D. Boyd, Morgan S. Ullrich, Li Liu, Duane D. Winkler   +4 more
openalex   +1 more source

Drug Repurposing Screen Identifies Pimozide as a ROS‐Inducing Therapy With Anti‐Tumor Efficacy in HNSCC PDX Models

Cancer Science, EarlyView.
A drug repurposing screen for reactive oxygen species (ROS)‐inducing compounds identified Pimozide as a potent anti‐tumor agent in head and neck squamous cell carcinoma (HNSCC) patient‐derived xenograft (PDX) models. Combined treatment with paclitaxel markedly reduced undifferentiated tumor cells.
Shogo Okazaki, Shintaro Nakamura, Tomoya Soma, Momoko Yoshikawa, Seiji Asoda, Yurika Nakajima, Kenji Tsuchihashi, Mitsuyo Ohmura, Ryo Goitsuka, Kenichi Imai, Hideyuki Saya, Osamu Nagano, Hiroyuki Ozawa   +12 more
wiley   +1 more source

BMP-Dependent Modulation of ROS Generation and Scavenging Controls Interdigital Cell Death. [PDF]

Dev Growth Differ
BMP signaling regulates ROS generation and scavenging to control interdigital cell death in the developing chicken limb, highlighting a balance between oxidative stress and tissue regression. ABSTRACT Programmed cell death during embryonic development plays a vital role in shaping limb morphology in amniotes.
Ono SF, Furukawa R, Cordeiro IR, Kabashima K, Yoshida K, Hatano T, Hayafune K, Kashima M, Kagehira A, Yu R, Kawanishi T, Tanaka M.   +11 more
europepmc   +2 more sources

Amyotrophic Lateral Sclerosis [PDF]

, 2019
The word amyotrophic is derived from Greek, and means “without nourishment to muscles”, lateral means to the sides and sclerosis means hardened (“What is ALS?,” n.d.).
Georgetson, Anastasia M.
core   +1 more source

In‐Tumor CRISPR‐Cas9 Knockout Screening and Novel Therapy Development for Malignant Transformation of Ovarian Teratoma

Cancer Science, EarlyView.
We conducted an in vivo genome‐wide CRISPR‐Cas9 knockout screen using MTMCT‐derived cells to identify genes essential for tumor growth. SOD1 emerged as a key therapeutic target, and its inhibition suppressed tumor proliferation by disrupting redox homeostasis, both in vitro and in PDX models. ABSTRACT Malignant transformation of mature cystic teratoma (
Satoshi Tamauchi, Kosuke Yoshida, Wang Xinyuan, Atsushi Nakagawa, Akira Yokoi, Nobuhisa Yoshikawa, Kaoru Niimi, Yusuke Yamamoto, Hiroaki Kajiyama   +8 more
wiley   +1 more source