Results 171 to 180 of about 74,541 (281)

Lactate Dehydrogenase Inhibition Reverts the Fatty Acid‐Induced Neurotoxic Phenotype of Astrocytes

Glia, Volume 74, Issue 3, March 2026.
ALS models display increased LD accumulation. LD accumulation is linked to a neurotoxic phenotype in astrocytes. Lactate dehydrogenase inhibition reverts LD accumulation in ALS astrocytes. ABSTRACT Astrocytes are central to lipid metabolism in the central nervous system.
Daniel Esteve, Mariana Bresque, Daniel Okhuevbie, Sandhya Ramachandran, Mariana Pehar, Marcelo R. Vargas   +5 more
wiley   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Structural mechanisms and insights on multiple nanobodies binding diverse SOD1 epitopes. [PDF]

Commun Biol
Cheng S, Zhong C, Zhu H, Mu K, Jiang H, Zhong P, Ma Z, Liu X, Wang Z, Liu R, Ding Y.   +10 more
europepmc   +1 more source

A prion-like mechanism for the propagated misfolding of SOD1 from in silico modeling of solvated near-native conformers

, 2017
Eamonn F. Healy
openalex   +1 more source

CuII(atsm) improves the neurological phenotype and survival of SOD1G93A mice and selectively increases enzymatically active SOD1 in the spinal cord [PDF]

, 2017
James B. Hilton, Stephen W. Mercer, Nastasia K.-H. Lim, Noel G. Faux, Gojko Buncic, Joseph S. Beckman, Blaine R. Roberts, Paul S. Donnelly, Anthony R. White, Peter J. Crouch   +9 more
openalex   +1 more source

Genomic Insights Into the Use of Green Tea (Camellia sinensis) as a Functional Feed Additive in Sustainable Aquaculture

Aquaculture, Fish and Fisheries, Volume 6, Issue 1, February 2026.
ABSTRACT Aquaculture is the fastest‐growing sector of animal food production, yet it faces increasing challenges in maintaining fish health and sustainability due to the widespread use of antibiotics and synthetic feed additives. Green tea (Camellia sinensis), a natural source of polyphenols and bioactive compounds, has gained attention as a functional
Nahida Akter, Chiara Bordin, Mahima Ranjan Acharjee, S. M. Sertaz Islam, Md. Masum Reza, Mahedi Hasan, Arman Hossain, Azeez Olalekan Baki, Md. Abdullah Al Mamun Hridoy   +8 more
wiley   +1 more source

Rongbei Maimendong Decoction Promotes Radiosensitivity of Non-Small Cell Lung Cancer Cells by Inhibiting SOD1 Expression. [PDF]

Mediators Inflamm
Liu S, Pang X, Wang L, Zhan N, Wu S, Deng J, Jin K, Bai Y, Jiang D, Qi L, Li Z.   +10 more
europepmc   +1 more source

IFN-β Impairs Superoxide-Dependent Parasite Killing in Human Macrophages: Evidence for a Deleterious Role of SOD1 in Cutaneous Leishmaniasis [PDF]

, 2009
Ricardo Khouri, André Báfica, Maria da Purificação Pereira Silva, Almério Noronha, Jean‐Pierre Kolb, Juana Wietzerbin, Aldina Barral, Manoel Barral‐Netto, Johan Van Weyenbergh   +8 more
openalex   +1 more source

SKALE: An Interpretable Multiscale Machine Learning Model for Decoding Phase‐Specific Protein Aggregation in Neurodegenerative Proteinopathies

Aggregate, Volume 7, Issue 2, February 2026.
Protein aggregation drives diverse degenerative diseases, yet its molecular origins are difficult to predict. SKALE uses interpretable machine learning to link sequence, structure, and dynamics, revealing how local structural weakening triggers aggregation.
Wei Xuan Wilson Loo, Jia Shen Sio, Keyin Yap, Yan Shan Loo, Hui Xuan Lim, Shuangyue Zhang, Huitao Liu, Chen Seng Ng   +7 more
wiley   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source