Results 221 to 230 of about 72,561 (329)

Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria

, 2006
Han‐Xiang Deng, Yong Shi, Yoshiaki Furukawa, Hong Zhai, Ronggen Fu, Erdong Liu, George Gorrie, Mohammad Saeed, Wu-Yen Hung, Eileen H. Bigio, Thomas J. Lukas, Mauro C. Dal Canto, Thomas V. O’Halloran, Teepu Siddique   +13 more
openalex   +1 more source

Human amyotrophic lateral sclerosis/motor neuron disease: The disease‐associated microglial pathway is upregulated while APOE genotype governs risk and survival

Brain Pathology, Volume 35, Issue 6, November 2025.
ALS/MND‐related inflammation is investigated in the motor cortex and spinal cord by both transcriptomics and immunohistochemistry. This reveals greater inflammation in the spinal cord and highlights the disease‐associated microglial (DAM) phenotype characterized by ApoE, TREM2, and TYROBP.
Bridget A. Ashford, Julie E. Simpson, Charlotte Dawson, Delphine Boche, Johnathan Cooper‐Knock, Paul R. Heath, Daniel Fillingham, Charlie Appleby‐Mallinder, Wenbin Wei, Mark Dunning, J. Robin Highley   +10 more
wiley   +1 more source

Integrating genetic testing into management of all patients with amyotrophic lateral sclerosis: a critical juncture. [PDF]

CMAJ
Breiner A, Schellenberg KL, Shoesmith C.
europepmc   +1 more source

SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model [PDF]

, 2008
Maged M. Harraz, Jennifer J. Marden, Weihong Zhou, Yulong Zhang, Aislinn Williams, Victor S. Sharov, Kathryn Nelson, Meihui Luo, Henry L. Paulson, Christian Schöneich, John F. Engelhardt   +10 more
openalex   +1 more source

The Role of Micronutrients in Atherosclerosis: Mechanisms and Clinical Application

Journal of Cellular and Molecular Medicine, Volume 29, Issue 21, November 2025.
ABSTRACT Micronutrients, though required in relatively small quantities by the human body, are essential for maintaining normal physiological functions and play a crucial role in the prevention and management of various diseases. Atherosclerosis (AS) is a common chronic inflammatory condition that often presents without obvious symptoms in its early ...
Yuxin Ouyang, Weiwei Jiang, Xiongquan Long, Peng Mao, Pingping He, Xinping Ouyang   +5 more
wiley   +1 more source

Fc-receptor-mediated intracellular delivery of Cu/Zn-superoxyde dismutase (SOD1) protects against redox-induced apoptosis though a nitric oxide dependant mecanism.

, 2000
Ioanis Vouldoukis, Virginie Sivan, Marie‐Catherine Vozenin, Caroline Kamaté, Alphonse Calenda, Dominique Mazier, Bernard Dugas   +6 more
openalex   +1 more source

Systemic AAV6 Delivery Mediating RNA Interference Against SOD1: Neuromuscular Transduction Does Not Alter Disease Progression in fALS Mice [PDF]

, 2008
Chris Towne, Cédric Raoul, Bernard L. Schneider, Patrick Aebischer   +3 more
openalex   +1 more source

Impact of SOD1 Transcript Variants on Amyotrophic Lateral Sclerosis Severity. [PDF]

Int J Mol Sci
Bordoni M, Scarian E, Viola C, Dragoni F, Di Gerlando R, Rizzo B, Diamanti L, Gagliardi S, Pansarasa O.   +8 more
europepmc   +1 more source

Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death [PDF]

, 2008
Hristelina Ilieva, Koji Yamanaka, Shelle Malkmus, Osamu Kakinohana, Tony L. Yaksh, Martin Maršala, Don W. Cleveland   +6 more
openalex   +1 more source

Lysyl-tRNA Synthetase Is a Target for Mutant SOD1 Toxicity in Mitochondria [PDF]

, 2008
Hibiki Kawamata, Jordi Magrané, Catherine B. Kunst, Michael P. King, Giovanni Manfredi   +4 more
openalex   +1 more source